SNP rs nr | Genotype | p-value for interaction | All individuals | Normal Weigth | Over Weight | Obese | ||||
---|---|---|---|---|---|---|---|---|---|---|
BMI = 18.5-24.99 | BMI = 25.00-29.99 | BMI ≥ 30 | ||||||||
case/contr: 2869/4480 | case/control: 1332/2018 | case/control: 917/1463 | case/control: 374/619 | |||||||
OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | |||
FGFR2 2981582 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.23 (1.10-1.37) | 1.26 (1.07-1.48) | 1.18 (0.97-1.42) | 1.08 (0.80-1.46) | ||||||
aa | 1.48 (1.29-1.69) | 1.46 (1.18-1.80) | 1.57 (1.24-1.99) | 1.14 (0.78-1.66) | ||||||
Per Allele | 0.59 | 1.22 (1.14-1.30) | 1.34E-08 | 1.21 (1.10-1.35) | 2.03E-04 | 1.25 (1.11-1.40) | 2.20E-04 | 1.07 (0.89-1.29) | 0.49 | |
TNR09 3803662 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.14 (1.03-1.26) | 1.16 (1.00-1.35) | 1.13 (0.94-1.34) | 1.27 (0.97-1.67) | ||||||
aa | 1.39 (1.17-1.67) | 1.44 (1.10-1.89) | 1.21 (0.89-1.65) | 1.72 (1.07-2.78) | ||||||
Per Allele | 0.72 | 1.16 (1.08-1.25) | 5.34E-05 | 1.18 (1.06-1.32) | 2.88E-03 | 1.11 (0.98-1.26) | 0.11 | 1.30 (1.06-1.58) | 0.01 | |
MAP3K1 889312 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.21 (1.09-1.34) | 1.15 (0.99-1.33) | 1.33 (1.11-1.58) | 1.21 (0.92-1.59) | ||||||
aa | 1.29 (1.09-1.54) | 1.22 (0.94-1.59) | 1.63 (1.20-2.22) | 1.22 (0.76-1.97) | ||||||
Per Allele | 0.47 | 1.17 (1.08-1.26) | 4.26E-05 | 1.12 (1.01-1.25) | 0.04 | 1.30 (1.14-1.48) | 8.64E-05 | 1.15 (0.94-1.40) | 0.18 | |
8q24 13281615 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.12 (1.00-1.24) | 1.18 (1.01-1.39) | 1.04 (0.86-1.25) | 1.13 (0.84-1.52) | ||||||
aa | 1.15 (1.00-1.32) | 1.22 (0.99-1.49) | 1.14 (0.90-1.45) | 1.10 (0.75-1.60) | ||||||
Per Allele | 0.82 | 1.08 (1.01-1.15) | 0.03 | 1.11 (1.01-1.23) | 0.04 | 1.06 (0.95-1.20) | 0.30 | 1.06 (0.88-1.27) | 0.54 | |
LSP1 3817198 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.12 (1.02-1.24) | 1.16 (0.99-1.34) | 1.11 (0.93-1.33) | 0.94 (0.72-1.24) | ||||||
aa | 1.19 (1.00-1.40) | 1.41 (1.10-1.81) | 1.06 (0.80-1.42) | 0.83 (0.50-1.38) | ||||||
Per Allele | 0.35 | 1.10 (1.02-1.18) | 8.65E-03 | 1.18 (1.06-1.31) | 3.22E-03 | 1.06 (0.93-1.20) | 0.38 | 0.93 (0.75-1.14) | 0.47 | |
2q35 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.05 (0.93-1.19) | 1.04 (0.87-1.24) | 1.00 (0.81-1.23) | 1.12 (0.80-1.58) | ||||||
aa | 1.20 (1.05-1.37) | 1.09 (0.89-1.33) | 1.28 (1.01-1.61) | 1.38 (0.94-2.03) | ||||||
Per Allele | 0.63 | 1.10 (1.03-1.17) | 7.47E-03 | 1.04 (0.94-1.15) | 0.40 | 1.13 (1.01-1.27) | 0.04 | 1.18 (0.97-1.43) | 0.09 | |
ESR1 7766585 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 1.23 (1.10-1.37) | 1.29 (1.09-1.52) | 1.18 (0.97-1.43) | 1.07 (0.79-1.44) | ||||||
aa | 1.02 (0.74-1.41) | 0.98 (0.60-1.61) | 1.27 (0.76-2.14) | 0.51 (0.18-1.41) | ||||||
Per Allele | 0.47 | 1.16 (1.05-1.27) | 2.66E-03 | 1.19 (1.03-1.37) | 0.02 | 1.16 (0.99-1.37) | 0.07 | 0.96 (0.74-1.24) | 0.75 | |
HCN1 981782 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 0.97 (0.87-1.09) | 1.04 (0.87-1.24) | 1.01 (0.82-1.23) | 0.87 (0.63-1.20) | ||||||
aa | 0.86 (0.75-0.99) | 0.84 (0.68-1.04) | 1.00 (0.79-1.28) | 0.87 (0.59-1.27) | ||||||
Per Allele | 0.50 | 0.93 (0.87-1.00) | 0.04 | 0.92 (0.83-1.02) | 0.13 | 1.00 (0.89-1.13) | 0.98 | 0.93 (0.77-1.13) | 0.46 | |
ESR1 851987 | AA | 1 | 1 | 1 | 1 | |||||
Aa | 0.91 (0.82-1.02) | 0.91 (0.78-1.06) | 0.97 (0.80-1.17) | 0.92 (0.69-1.22) | ||||||
aa | 0.88 (0.74-1.05) | 0.92 (0.71-1.20) | 0.83 (0.61-1.13) | 0.76 (0.46-1.25) | ||||||
Per Allele | 0.89 | 0.93 (0.86-1.00) | 0.06 | 0.94 (0.84-1.05) | 0.29 | 0.93 (0.81-1.07) | 0.30 | 0.89 (0.72-1.10) | 0.28 |