SNP rs nr | Genotype | p-value for interaction | All individuals* | HRT Non Users* | HRT Current Users* | HRT Estrogen* | HRT Comb* | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
case/contr: 2869/4480 | case/contr: 1536/2949 | case/contr: 494/800 | case/contr: 185/324 | case/contr:298/455 | ||||||||
OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | |||
FGFR2 2981582 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.23 (1.10-1.37) | 1.22 (1.06-1.41) | 1.16 (0.89-1.50) | 1.15 (0.75-1.75) | 1.17 (0.83-1.65) | |||||||
aa | 1.48 (1.29-1.69) | 1.55 (1.29-1.89) | 1.63 (1.17-2.26) | 1.44 (0.86-2.42) | 1.87 (1.21-2.89) | |||||||
Per Allele | 0,83 | 1.22 (1.14-1.30) | 1.34E-08 | 1.24 (1.14-1.36) | 2.04E-06 | 1.26 (1.07-1.49) | 4.83E-03 | 1.20 (0.92-1.55) | 0.18 | 1.34 (1.08-1.66) | 7.30E-03 | |
TNRC9 3803662 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.14 (1.03-1.26) | 1.15 (1.01-1.31) | 1.17 (0.91-1.49) | 1.31 (0.89-1.94) | 1.13 (0.83-1.56) | |||||||
aa | 1.39 (1.17-1.67) | 1.48 (1.18-1.86) | 1.47 (0.96-2.27) | 1.56 (0.79-3.11) | 1.53 (0.86-2.69) | |||||||
Per Allele | 0,98 | 1.16 (1.08-1.25) | 5.34E-05 | 1.19 (1.08-1.31) | 3.74E-04 | 1.19 (1.00-1.43) | 0.05 | 1.28 (0.96-1.70) | 0.09 | 1.19 (0.94-1.51) | 0.15 | |
MAP3K1 889312 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.21 (1.09-1.34) | 1.27 (1.11-1.45) | 1.04 (0.82-1.32) | 0.87 (0.59-1.29) | 1.13 (0.82-1.54) | |||||||
aa | 1.29 (1.09-1.54) | 1.20 (0.95-1.53) | 1.54 (1.02-2.33) | 1.81 (0.98-3.33) | 1.31 (0.74-2.33) | |||||||
Per Allele | 0,12 | 1.17 (1.08-1.26) | 4.26E-05 | 1.17 (1.06-1.29) | 1.90E-03 | 1.15 (0.97-1.38) | 0.11 | 1.16 (0.88-1.52) | 0.28 | 1.14 (0.90-1.44) | 0.29 | |
8q24 13281615 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.12 (1.00-1.24) | 1.20 (1.04-1.39) | 1.05 (0.81-1.34) | 0.90 (0.60-1.36) | 1.10 (0.80-1.53) | |||||||
aa | 1.15 (1.00-1.32) | 1.43 (1.20-1.71) | 0.86 (0.61-1.20) | 0.88 (0.52-1.51) | 0.84 (0.53-1.32) | |||||||
Per Allele | 0,03 | 1.08 (1.01-1.15) | 0.03 | 1.20 (1.10-1.31) | 6.10E-05 | 0.95 (0.81-1.12) | 0.52 | 0.93 (0.72-1.22) | 0.61 | 0.95 (0.77-1.18) | 0.67 | |
LSP1 3817198 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.12 (1.02-1.24) | 1.13 (0.99-1.29) | 1.29 (1.01-1.65) | 1.32 (0.89-1.94) | 1.30 (0.95-1.80) | |||||||
aa | 1.19 (1.00-1.40) | 1.06 (0.85-1.31) | 1.68 (1.12-2.53) | 1.19 (0.61-2.33) | 2.35 (1.37-4.03) | |||||||
Per Allele | 0,13 | 1.10 (1.02-1.18) | 8.65E-03 | 1.06 (0.97-1.17) | 0.21 | 1.30 (1.09-1.55) | 4.07E-03 | 1.18 (0.89-1.56) | 0.26 | 1.44 (1.14-1.82) | 2.16E-03 | |
2q35 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.05 (0.93-1.19) | 1.05 (0.89-1.23) | 0.95 (0.72-1.27) | 0.77 (0.48-1.25) | 1.13 (0.78-1.63) | |||||||
aa | 1.20 (1.05-1.37) | 1.15 (0.97-1.38) | 1.20 (0.87-1.67) | 1.26 (0.75-2.10) | 1.20 (0.78-1.85) | |||||||
Per Allele | 0,68 | 1.10 (1.03-1.17) | 7.47E-03 | 1.08 (0.98-1.17) | 0.11 | 1.10 (0.93-1.29) | 0.26 | 1.14 (0.88-1.48) | 0.33 | 1.10 (0.88-1.36) | 0.40 | |
ESR1 7766585 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 1.23 (1.10-1.37) | 1.23 (1.07-1.43) | 1.05 (0.81-1.36) | 1.31 (0.85-2.03) | 0.88 (0.63-1.23) | |||||||
aa | 1.02 (0.74-1.41) | 1.01 (0.67-1.53) | 1.29 (0.61-2.73) | 1.43 (0.52-3.93) | 0.86 (0.26-2.81) | |||||||
Per Allele | 0,47 | 1.16 (1.05-1.27) | 2.66E-03 | 1.15 (1.02-1.31) | 0.02 | 1.07 (0.86-1.34) | 0.53 | 1.26 (0.89-1.79) | 0.19 | 0.89 (0.66-1.21) | 0.46 | |
HCN1 981782 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 0.97 (0.87-1.09) | 0.88 (0.76-1.02) | 1.15 (0.86-1.53) | 0.88 (0.57-1.38) | 1.34 (0.92-1.96) | |||||||
aa | 0.86 (0.75-0.99) | 0.80 (0.66-0.95) | 0.93 (0.66-1.31) | 0.74 (0.43-1.28) | 1.05 (0.67-1.64) | |||||||
Per Allele | 0,26 | 0.93 (0.87-1.00) | 0.04 | 0.89 (0.81-0.98) | 0.01 | 0.97 (0.82-1.14) | 0.70 | 0.86 (0.66-1.13) | 0.28 | 1.02 (0.82-1.27) | 0.84 | |
ESR1 851987 | AA | 1 | 1 | 1 | 1 | 1 | ||||||
Aa | 0.91 (0.82-1.02) | 0.94 (0.82-1.07) | 0.80 (0.62-1.04) | 0.94 (0.63-1.43) | 0.73 (0.52-1.03) | |||||||
aa | 0.88 (0.74-1.05) | 0.90 (0.72-1.13) | 0.93 (0.62-1.42) | 0.88 (0.46-1.68) | 0.96 (0.54-1.69) | |||||||
Per Allele | 0,52 | 0.93 (0.86-1.00) | 0.06 | 0.94 (0.86-1.04) | 0.24 | 0.90 (0.75-1.09) | 0.28 | 0.94 (0.70-1.25) | 0.67 | 0.87 (0.68-1.12) | 0.29 |