Table 2 Treatment by nutlin-3 results in a concentration dependent increase of the number of p53 positive cells as well as of the staining intensity as revealed by immunohistochemistry.

0694-2

control

11

0 - 1

n.d.

10 μM nutlin-3

72 h

393

2

n.d.

30 μM nutlin-3

1, 277

3

n.d.

0695-0

control

0

0

4%

10 μM nutlin-3

11

1

< 1%

30 μM nutlin-3

188

1

< 1%

0695-1

control

0

0

-

10 μM nutlin-3

42

0 - 1

-

30 μM nutlin-3

6 days

89

1

-

0695-2

control

0

0

< 1%

10 μM nutlin-3

194

1 - 2

-

30 μM nutlin-3

799

3

-

0695-3

control

0

0

< 1%

10 μM nutlin-3

770

3

30 μM nutlin-3

1, 493

3

0687-0

control

0

0

n.d.

10 μM nutlin-3

2

1

n.d.

30 μM nutlin-3

72 h

257

2

n.d.

0687-1

control

0

0

n.d.

10 μM nutlin-3

398

2

n.d.

30 μM nutlin-3

n.d.

n.d.

n.d.