Table 2 Potential confounders and nuclear individual ancestry in Uruguayan controls

Controls (N = 164)

Place of residence (N)

Montevideo (143)

9.3 ± 7.8

15.3 ± 11.6

75.4 ± 14.7

Rest of the country (21)

8.1 ± 5.2

10.5 ± 7.2

81.4 ± 7.8

p-value

0.81

0.13

0.16

Hospital (N)

Public (139)

9.5 ± 7.8

15.5 ± 11.7

75.1 ± 14.8

Private (25)

7.4 ± 5.4

10.2 ± 7.0

82.4 ± 6.8

p-value

0.27

0.07

0.05

Menopause (N)

Yes (91)

8.6 ± 7.6

13.9 ± 10.7

77.5 ± 14.6

No (69)

10.2 ± 7.4

16.1 ± 12.0

73.7 ± 13.4

p-value

0.05

0.32

0.04

Breast cancer in the family (N)

Yes (16)

8.6 ± 5.9

16.0 ± 12.6

75.4 ± 15.0

No (148)

9.2 ± 7.6

14.5 ± 11.1

76.3 ± 14.1

p-value

0.78

0.70

0.81

Education (N)

Primary school (53)

10.0 ± 8.1

17.6 ± 12.3

72.5 ± 16.0

Secondary school (71)

9.9 ± 7.9

15.4 ± 10.9

74.7 ± 13.1

University (40)

6.7 ± 5.1

9.5 ± 8.5

83.8 ± 10.2

p-value

0.08

0.001

<0.001

Socioeconomic status (N)

Low (53)

9.9 ± 8.1

16.7 ± 11.7

73.4 ± 15.6

Medium (111)

8.8 ± 7.2

13.7 ± 10.9

77.5 ± 13.3

p-value

0.41

0.07

0.13

Age at recruitment (mean change in years per 25% ancestry increase, 95% CI) (N = 164)

−0.56 (−1.75, 0.63)

0.08 (−1.17, 1.33)

0.52 (−0.68, 1.73)

p-value

0.36

0.90

0.39

Age at first child (mean change in years per 25% ancestry increase, 95% CI) (N = 139)

−0.44 (−1.26, 0.39)

−0.91 (−1.78, −0.03)

0.94 (0.11, 1.78)

p-value

0.30

0.04

0.03

Age at menopause (mean change in years per 25% ancestry increase, 95% CI) (N = 49)^a

−0.94 (−1.90, 0.02)

−1.60 (−2.66, −0.54)

1.43 (0.46, 2.40)

p-value

0.05

0.004

0.01