Minor themes for three major factors (patient-, trial- and sociocultural-related) | Number of respondents |
---|---|
Patient-related factors | Â |
Facilitators: | Â |
• Opinion of family and friends | 12 |
• If test therapy is last resort (late stage/failure of current therapy) | 6 |
• If overall benefits outweigh risks | 2 |
• If general health is better | 2 |
• Altruism | 6 |
Barriers: | Â |
• Previous bad experiences with doctors, trials, and drugs | 3 |
• Conservative attitude towards risk-taking | 2 |
• Unique health situation | 2 |
• Cancer is a serious illness | 1 |
Trial/protocol-related factors | Â |
Facilitators: | Â |
• Hope that test therapy is better treatment option | 9 |
• Closer monitoring | 3 |
• Lower cost of treatment | 3 |
• Trust that care is adequate during trial procedure | 2 |
Barriers: | Â |
• Risk of test therapy/Uncertainties inherent in investigational drugs | 13 |
• Perceived risk associated with randomisation | 5 |
• Additional visits required | 5 |
• Systemic therapy | 2 |
• Added stress from trials | 2 |
• Additional tests required | 1 |
Broader Socio-cultural/System-related factors | Â |
Facilitators: | Â |
• Trust in physicians | 7 |
• Trust in drug development/regulation and healthcare system | 8 |
Barriers: | Â |
• Fatalism | 1 |