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Fig. 3 | BMC Women's Health

Fig. 3

From: LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma

Fig. 3

WWTR1-AS1 and miR-136 interacted with each other but did not regulate the expression of each other. IntaRNA 2.0 was applied to predict the binding of WWTR1-AS1 to miR-136 (A), which was further confirmed by dual luciferase activity assay (B). SiHa cells were transfected with either WWTR1-AS1 expression vector or miR-136 mimic, and the overexpression of WWTR1-AS1 WT/MUT and miR-136 was confirmed by RT-qPCR (C). The role of WWTR1-AS1 WT/MUT and miR-136 in regulating the expression of each other was studied by performing RT-qPCR (D). Control (C) cells were untransfected cells. NC cells were miR-NC mimics - or empty vector-transfected cells. *, p < 0.05

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BMC Women's Health

ISSN: 1472-6874

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