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Table 2 The odds ratio (95% confidence interval) of breast cancer based on the different high protein scores in tertiles or per increment of one standard deviation among the study population

From: High-protein diet scores, macronutrient substitution, and breast cancer risk: insights from substitution analysis

 

OR of breast cancer (95% CI)

  

T1

T2

T3

P trend

Per one SD

P-value

High-protein-low-CHO and fat diet

    Median score, SD

12.0

17.0

21.0

-

3.83

-

    Case/total

58 / 138

36 / 133

40 / 130

-

134 / 401

-

    Model 1a

1.00 (Ref)

0.52 (0.31–0.89)

0.65 (0.39–1.08)

0.068

0.80 (0.65–1.00)

0.045

    Model 2b

1.00 (Ref)

0.45 (0.26–0.78)

0.58 (0.34–1.00)

0.031

0.77 (0.61–0.96)

0.022

    Model 3c

1.00 (Ref)

0.39 (0.22–0.69)

0.48 (0.27–0.85)

0.008

0.71 (0.56–0.90)

0.005

High-protein and CHO-low-fat score

      

    Median score, SD

10.0

18.0

24.0

-

6.73

-

    Case/total

58 / 156

42 / 118

34 / 127

-

134 / 401

-

    Model 1a

1.00 (Ref)

0.96 (0.57–1.60)

0.66 (0.39–1.11)

0.143

0.85 (0.69–1.06)

0.146

    Model 2b

1.00 (Ref)

0.91 (0.53–1.55)

0.63 (0.36–1.10)

0.115

0.81 (0.64–1.02)

0.070

    Model 3c

1.00 (Ref)

0.84 (0.49–1.45)

0.58 (0.33–1.01)

0.061

0.76 (0.60–0.97)

0.026

High-protein and fat-low-CHO score

    Median score, SD

10.0

17.0

23.0

-

5.92

-

    Case/total

49 / 139

43 / 135

42 / 127

-

134 / 401

-

    Model 1a

1.00 (Ref)

0.82 (0.49–1.37)

0.89 (0.53–1.50)

0.631

0.99 (0.80–1.22)

0.913

    Model 2b

1.00 (Ref)

0.72 (0.42–1.24)

0.91 (0.52–1.58)

0.655

0.99 (0.79–1.24)

0.941

    Model 3c

1.00 (Ref)

0.73 (0.42–1.25)

0.91 (0.52–1.59)

0.665

0.99 (0.79–1.24)

0.908

  1. CHO Carbohydrate
  2. aModel 1: adjusted for age, first pregnancy age
  3. bModel 2: adjusted for model 1 and menopausal status, family history of cancer, anti-inflammatory drug use, Vitamin D supplementation, physical activity, body mass index, and socio-economic status
  4. cModel 3: adjusted for model 2 and energy intake