High-protein diet scores, macronutrient substitution, and breast cancer risk: insights from substitution analysis

BMC Women's Health

Table 3 Substitution analysis for the association of replacing macronutrients together on the odds of breast cancer calculated using logistic regression models^a

Substituting X instead of Y	per 50 Kcal		per 100 Kcal
Substituting X instead of Y	OR differences (95% CI)	P-value	OR differences (95% CI)	P-value
Protein instead of CHO	-0.10 (-0.31, 0.10)	0.325	-0.21 (-0.63, 0.21)	0.325
Protein instead of fat	-0.20 (-0.36, -0.03)	0.016	-0.40 (-0.73, -0.07)	0.016
Plant protein instead of animal protein	-0.14 ( -0.44. 0.15)	0.351	-0.28 (-0.88, 0.31)	0.351
Plant protein instead of refined CHO	-0.33 (-0.63, -0.03)	0.028	-0.66 (-1.26, -0.07)	0.028
Plant protein instead of animal fat	-0.20 (-0.46, 0.05)	0.126	-0.40 (-0.92, 1.11)	0.126

CHO Carbohydrate
^aAll analyses were adjusted for age, first pregnancy age, menopausal status, family history of cancer, anti-inflammatory drug use, vitamin D supplementation, physical activity, body mass index, socio-economic status, and energy intake

ISSN: 1472-6874