Table 3 The multivariable hazard ratio (HR) and 95% confidence intervals (CI) of association between weight change categories and incident HTN: Tehran Lipid and Glucose Study (TLGS), Iran, 1999–2018

Weight change categories ref = ± 3%

(normal)

Lost > 5%

0.50(0.36, 0.69)

< 0.001

0.26

0.44 (0.32,0.62)

< 0.001

0.39

Lost 3–5%

0.49(0.28, 0.86)

0.01

0.47 (0.26,0.84)

0.01

Gained 3–5%

1.10(0.76, 1.61)

0.58

1.02 (0.70,1.50)

0.88

Gained > 5%

0.76(0.57, 1.00)

0.05

0.69 (0.51,0.91)

0.01

Menopausal age (ref = Normal)

Early

0.73(0.52, 1.02)

0.07

0.79

0.83 (0.56,1.23)

0.36

Surgical early

0.96(0.70, 1.32)

084

1.03 (0.68,1.54)

0.88

Difference of menopause age and baseline age(ref = 0–5 years)

5–10 years

0.95(0.70, 1.30)

0.78

0.81

0.93 (0.67,1.31)

0.71

> 10 years

0.89(0.64, 1.25)

0.52

0.91 (0.58,1.42)

0.69

Age (Years)

-

-

-

-

1.04 (1.01,1.08)

0.004

BMI (Kg/m²)

-

-

-

-

1.02 (1.00,1.05)

0.030

Parity

-

1.04(0.99, 1.10)

0.06

0.77

1.04 (0.98,1.09)

0.13

HDL

-

0.99(0.98, 1.00)

0.09

0.75

0.99 (0.97,1.01)

0.60

LDL

-

0.99(0.99, 1.00)

0.75

0.58

0.99 (0.98,1.01)

0.84

TG

-

1.00(0.99, 1.00)

0.47

0.85

1.00 (0.99,1.00)

0.85

FBS

-

1.01(1.00, 1.01)

< 0.001

0.71

1.00 (1.00,1.01)

< 0.001

TC

-

0.99(0.99, 1.00)

0.70

0.55

0.99 (0.98,1.01)

0.97

Smoking status (ref = No)

Yes

1.66 (1.010,2.50)

0.015

0.37

1.70 (1.11,2.58)

0.01

Physical activity (ref = Low)

Appropriate

0.88(0.69, 1.13)

0.33

0.38

0.97 (0.75,1.24)

0.82

Family history of CVD (ref = No)

Yes

1.31(0.98, 1.74)

0.06

0.87

1.23 (0.90,1.68)

0.18