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Table 2 Unadjusted and Adjusted Odds Ratio (OR) and 95% Confidence Interval (CI) for Placental Abruption in Relation to Maternal History of Headaches and Migraine, Lima, Peru, 2006-2008

From: Risk of placental abruption in relation to migraines and headaches

  Placental Abruption   
  Cases (N = 375) Controls (N = 368)   
Exposure Status n % n % Unadjusted
OR (95% CI)
1Adjusted
OR (95% CI)
Lifetime History of Headaches and Migraine (ICHD Criteria)    
   No 225 60.0 259 70.4   
   Yes 150 40.0 109 29.6 1.58 (1.17-2.15) 1.60 (1.16-2.20)
Migraine headache 44 11.7 23 6.3 2.20 (1.29-3.76) 2.14 (1.22-3.75)
Tension-type headaches 51 13.6 38 10.3 1.54 (0.98-2.44) 1.61 (1.01-2.57)
Other headaches 55 14.7 48 13.0 1.32 (0.86-2.02) 1.35 (0.87-2.09)
Lifetime History of Migraine with aura(ICHD criteria) 2     
   No Headaches or Migraine 225 60.0 259 70.4 1.00 (referent) 1.00 (referent)
Migraine without aura 23 6.1 12 3.3 2.21 (1.07-4.53) 2.11 (1.00-4.45)
Migraine with aura 21 5.6 11 3.0 2.20 (1.04-4.66) 1.59 (0.70-3.62)
Onset of Migraine (ICHD criteria) 2       
   No Headaches or Migraine 225 60.0 259 70.4 1.00 (referent) 1.00 (referent)
Yes, onset during pregnancy 5 1.3 2 0.5 2.88 (0.55-14.98) 2.63 (0.48-14.44)
Yes, onset prior to pregnancy 39 10.4 21 5.7 2.14 (1.22-3.74) 1.79 (0.98-3.27)
Headache or Migraine Onset       
   No headache 225 60.0 259 70.4 1.00 (referent) 1.00 (referent)
   Final month of pregnancy 5 1.3 3 0.8 1.92 (0.45-8.12) 1.67 (0.39-7.24)
   First 8 months of pregnancy 34 9.1 24 6.5 1.63 (0.94-2.83) 1.62 (0.92-2.85)
   Prior to pregnancy 111 29.6 82 22.3 1.56 (1.11-2.18) 1.66 (1.16-2.37)
History of Physician Diagnosed Migraine      
   No 350 93.3 348 94.6 1.00 (referent) 1.00 (referent)
   Yes 25 6.7 20 5.4 1.24 (0.68-2.28) 1.13 (0.60-2.12)
  1. 1Adjusted by maternal age, education, smoking status, alcohol consumption, prenatal care utilization and maternal depression status
  2. 2Women with non-migrainous headache disorders were deleted from this analysis; column percentages will not sum to 100%