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Table 4 Results of linear regression analysis (unadjusted and adjusted) for the relationship between patterns of oral contraceptive use and IGF-1 levels (ng/ml) for women aged 31 to 40 years.

From: A cross-sectional study of different patterns of oral contraceptive use among premenopausal women and circulating IGF-1: implications for disease risk

   

Unadjusted

Adjusteda

 

No.

Mean (SD)

Beta

95%CI

P

Beta

95%CI

P

OC Use

        

Never

37

167.2 (58.7)

Reference

0.37

Reference

0.30

Ever

111

176.8 (56.1)

9.6

-11.7, 30.9

 

10.8

-9.7, 31.3

 

Never

37

167.2 (58.7)

Reference

0.18

Reference

0.09

Past

87

181.4 (56.9)

14.2

-7.7, 36.1

 

16.4

-4.7, 37.6

 

Current

24

160.2 (51.1)

-7.0

-36.3, 22.2

 

-7.7

-35.6, 20.2

 

Age at first use

        

Never

37

167.2 (58.7)

Reference

0.04

Reference

0.04

Current

24

160.2 (51.1)

-7.0

-35.8, 21.7

 

-7.8

-35.4, 19.8

 

Past

        

≤ 18 years

47

168.8 (52.7)

1.4

-22.5, 25.7

 

5.5

-17.8, 28.9

 

19 to 24 years

28

188.8 (61.0)

21.5

-5.9, 49.0

 

22.5

-4.2, 49.1

 

≥ 25 years

12

213.8 (50.6)

46.5

10.1, 83.0

 

43.8

8.8, 78.8

 

Time since first use

        

Never

37

167.2 (58.7)

Reference

0.01

Reference

0.03

Current

24

160.2 (51.1)

-7.0

-35.4, 21.3

 

-7.5

-35.0, 19.9

 

Past

        

≥ 20 years

25

156.0 (47.4)

-11.3

-39.3, 16.8

 

-1.4

-29.3, 26.4

 

15 to 19 years

32

179.2 (54.5)

12.0

-14.2, 38.1

 

11.8

-13.7, 37.4

 

< 15 years

30

205.0 (58.4)

37.8

11.2, 64.4

 

35.1

9.3, 61.0

 

Time since last use

        

Never

37

167.2 (58.7)

Reference

0.35

Reference

0.30

Current

24

160.2 (51.1)

-7.0

-36.4, 22.3

 

-7.7

-35.8, 20.4

 

Past

        

<5 years

26

183.0 (58.1)

15.7

-12.9, 44.4

 

14.4

-13.0, 42.0

 

5 to <10 years

29

188.3 (61.9)

21.1

-6.7, 48.8

 

20.7

-6.1, 47.6

 

≥ 10 years

32

173.9 (51.7)

6.7

-20.3, 33.8

 

14.2

-12.0, 40.5

 

Duration of use

        

Never

37

167.2 (58.7)

Reference

0.23

Reference

0.22

Current

24

160.2 (51.1)

-7.0

-36.3, 22.2

 

-7.7

-35.7, 20.3

 

Past

        

<5 years

21

197.0 (65.2)

29.8

-0.7, 60.2

 

25.8

-3.6, 55.2

 

5 to < 10 years

33

178.6 (50.2)

11.4

-15.3, 38.1

 

16.3

-9.5, 42.0

 

≥ 10 years

33

174.3 (57.4)

7.1

-19.6, 33.8

 

10.2

-15.7, 36.2

 

Year of first use

        

Never

37

167.2 (58.7)

Reference

0.03

Reference

0.02

Current

24

160.2 (51.1)

-7.0

-35.9, 21.8

 

-8.1

-35.6, 19.4

 

Past

        

1979 to 1994

73

175.4 (54.8)

8.2

-14.0, 30.4

 

10.8

-10.6, 32.2

 

1995 to 2004

14

212.9 (59.2)

45.6

11.1, 80.1

 

46.6

13.4, 79.8

 
  1. a Adjusted for current weight (75th percentile and above vs. below), days since last reported menstrual cycle (<=14 vs. >14), and current physical activity at least once per week (ever vs. never)