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Table 4 Results of linear regression analysis (unadjusted and adjusted) for the relationship between patterns of oral contraceptive use and IGF-1 levels (ng/ml) for women aged 31 to 40 years.

From: A cross-sectional study of different patterns of oral contraceptive use among premenopausal women and circulating IGF-1: implications for disease risk

    Unadjusted Adjusteda
  No. Mean (SD) Beta 95%CI P Beta 95%CI P
OC Use         
Never 37 167.2 (58.7) Reference 0.37 Reference 0.30
Ever 111 176.8 (56.1) 9.6 -11.7, 30.9   10.8 -9.7, 31.3  
Never 37 167.2 (58.7) Reference 0.18 Reference 0.09
Past 87 181.4 (56.9) 14.2 -7.7, 36.1   16.4 -4.7, 37.6  
Current 24 160.2 (51.1) -7.0 -36.3, 22.2   -7.7 -35.6, 20.2  
Age at first use         
Never 37 167.2 (58.7) Reference 0.04 Reference 0.04
Current 24 160.2 (51.1) -7.0 -35.8, 21.7   -7.8 -35.4, 19.8  
Past         
≤ 18 years 47 168.8 (52.7) 1.4 -22.5, 25.7   5.5 -17.8, 28.9  
19 to 24 years 28 188.8 (61.0) 21.5 -5.9, 49.0   22.5 -4.2, 49.1  
≥ 25 years 12 213.8 (50.6) 46.5 10.1, 83.0   43.8 8.8, 78.8  
Time since first use         
Never 37 167.2 (58.7) Reference 0.01 Reference 0.03
Current 24 160.2 (51.1) -7.0 -35.4, 21.3   -7.5 -35.0, 19.9  
Past         
≥ 20 years 25 156.0 (47.4) -11.3 -39.3, 16.8   -1.4 -29.3, 26.4  
15 to 19 years 32 179.2 (54.5) 12.0 -14.2, 38.1   11.8 -13.7, 37.4  
< 15 years 30 205.0 (58.4) 37.8 11.2, 64.4   35.1 9.3, 61.0  
Time since last use         
Never 37 167.2 (58.7) Reference 0.35 Reference 0.30
Current 24 160.2 (51.1) -7.0 -36.4, 22.3   -7.7 -35.8, 20.4  
Past         
<5 years 26 183.0 (58.1) 15.7 -12.9, 44.4   14.4 -13.0, 42.0  
5 to <10 years 29 188.3 (61.9) 21.1 -6.7, 48.8   20.7 -6.1, 47.6  
≥ 10 years 32 173.9 (51.7) 6.7 -20.3, 33.8   14.2 -12.0, 40.5  
Duration of use         
Never 37 167.2 (58.7) Reference 0.23 Reference 0.22
Current 24 160.2 (51.1) -7.0 -36.3, 22.2   -7.7 -35.7, 20.3  
Past         
<5 years 21 197.0 (65.2) 29.8 -0.7, 60.2   25.8 -3.6, 55.2  
5 to < 10 years 33 178.6 (50.2) 11.4 -15.3, 38.1   16.3 -9.5, 42.0  
≥ 10 years 33 174.3 (57.4) 7.1 -19.6, 33.8   10.2 -15.7, 36.2  
Year of first use         
Never 37 167.2 (58.7) Reference 0.03 Reference 0.02
Current 24 160.2 (51.1) -7.0 -35.9, 21.8   -8.1 -35.6, 19.4  
Past         
1979 to 1994 73 175.4 (54.8) 8.2 -14.0, 30.4   10.8 -10.6, 32.2  
1995 to 2004 14 212.9 (59.2) 45.6 11.1, 80.1   46.6 13.4, 79.8  
  1. a Adjusted for current weight (75th percentile and above vs. below), days since last reported menstrual cycle (<=14 vs. >14), and current physical activity at least once per week (ever vs. never)
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