Association between low-dose pulsed intravenous cyclophosphamide therapy and amenorrhea in patients with systemic lupus erythematosus: A case-control study

Table 4 Comparisons of menses resumption by age or treatment regimen groups

	Resumed menses	Sustained amenorrhea	p*	OR^† (95% CI)
	n = 21	n = 5
Treatment regimen
IVCY group^‡	13 (62%)	4 (80%)	0.63	2.5 (0.2-26.1)
Steroid group^‡	8 (38%)	1 (20%)		-
Age
< 40 years old	17 (81%)	0 (0%)	0.002	-
≥ 40 years old	4 (19%)	5 (100%)		-
Age < 40 years old
IVCY group^‡	11 (52%)	0 (0%)	1.00	-
Steroid group^‡	6 (29%)	0 (0%)		-
Age ≥ 40 years-old
IVCY group^‡	2 (10%)	4 (80%)	0.52	4.0 (0.2-75.7)
Steroid group^‡	2 (10%)	1 (20%)		-

*p values were determined by Fisher's exact test.
^†ORs were defined as the ratios of the odds of sustained amenorrhea.
^‡Patients with SLE were divided into 2 groups: those who received low-dose IVCY plus high-dose glucocorticoids (IVCY group) and those who received high-dose glucocorticoids alone (steroid group).
IVCY intravenous cyclophosphamide, SLE systemic lupus erythematosus, OR odds ratio, CI confidence interval.

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