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Table 3 OR adjusted for Age and Study Population, stratified by BMI

From: Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

SNP rs nr

Genotype

p-value for interaction

All individuals

Normal Weigth

Over Weight

Obese

    

BMI = 18.5-24.99

BMI = 25.00-29.99

BMI ≥ 30

   

case/contr: 2869/4480

case/control: 1332/2018

case/control: 917/1463

case/control: 374/619

   

OR 95%CI

p-trend

OR 95%CI

p-trend

OR 95%CI

p-trend

OR 95%CI

p-trend

FGFR2 2981582

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.23 (1.10-1.37)

 

1.26 (1.07-1.48)

 

1.18 (0.97-1.42)

 

1.08 (0.80-1.46)

 
 

aa

 

1.48 (1.29-1.69)

 

1.46 (1.18-1.80)

 

1.57 (1.24-1.99)

 

1.14 (0.78-1.66)

 
 

Per Allele

0.59

1.22 (1.14-1.30)

1.34E-08

1.21 (1.10-1.35)

2.03E-04

1.25 (1.11-1.40)

2.20E-04

1.07 (0.89-1.29)

0.49

TNR09 3803662

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.14 (1.03-1.26)

 

1.16 (1.00-1.35)

 

1.13 (0.94-1.34)

 

1.27 (0.97-1.67)

 
 

aa

 

1.39 (1.17-1.67)

 

1.44 (1.10-1.89)

 

1.21 (0.89-1.65)

 

1.72 (1.07-2.78)

 
 

Per Allele

0.72

1.16 (1.08-1.25)

5.34E-05

1.18 (1.06-1.32)

2.88E-03

1.11 (0.98-1.26)

0.11

1.30 (1.06-1.58)

0.01

MAP3K1 889312

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.21 (1.09-1.34)

 

1.15 (0.99-1.33)

 

1.33 (1.11-1.58)

 

1.21 (0.92-1.59)

 
 

aa

 

1.29 (1.09-1.54)

 

1.22 (0.94-1.59)

 

1.63 (1.20-2.22)

 

1.22 (0.76-1.97)

 
 

Per Allele

0.47

1.17 (1.08-1.26)

4.26E-05

1.12 (1.01-1.25)

0.04

1.30 (1.14-1.48)

8.64E-05

1.15 (0.94-1.40)

0.18

8q24 13281615

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.12 (1.00-1.24)

 

1.18 (1.01-1.39)

 

1.04 (0.86-1.25)

 

1.13 (0.84-1.52)

 
 

aa

 

1.15 (1.00-1.32)

 

1.22 (0.99-1.49)

 

1.14 (0.90-1.45)

 

1.10 (0.75-1.60)

 
 

Per Allele

0.82

1.08 (1.01-1.15)

0.03

1.11 (1.01-1.23)

0.04

1.06 (0.95-1.20)

0.30

1.06 (0.88-1.27)

0.54

LSP1 3817198

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.12 (1.02-1.24)

 

1.16 (0.99-1.34)

 

1.11 (0.93-1.33)

 

0.94 (0.72-1.24)

 
 

aa

 

1.19 (1.00-1.40)

 

1.41 (1.10-1.81)

 

1.06 (0.80-1.42)

 

0.83 (0.50-1.38)

 
 

Per Allele

0.35

1.10 (1.02-1.18)

8.65E-03

1.18 (1.06-1.31)

3.22E-03

1.06 (0.93-1.20)

0.38

0.93 (0.75-1.14)

0.47

2q35

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.05 (0.93-1.19)

 

1.04 (0.87-1.24)

 

1.00 (0.81-1.23)

 

1.12 (0.80-1.58)

 
 

aa

 

1.20 (1.05-1.37)

 

1.09 (0.89-1.33)

 

1.28 (1.01-1.61)

 

1.38 (0.94-2.03)

 
 

Per Allele

0.63

1.10 (1.03-1.17)

7.47E-03

1.04 (0.94-1.15)

0.40

1.13 (1.01-1.27)

0.04

1.18 (0.97-1.43)

0.09

ESR1 7766585

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

1.23 (1.10-1.37)

 

1.29 (1.09-1.52)

 

1.18 (0.97-1.43)

 

1.07 (0.79-1.44)

 
 

aa

 

1.02 (0.74-1.41)

 

0.98 (0.60-1.61)

 

1.27 (0.76-2.14)

 

0.51 (0.18-1.41)

 
 

Per Allele

0.47

1.16 (1.05-1.27)

2.66E-03

1.19 (1.03-1.37)

0.02

1.16 (0.99-1.37)

0.07

0.96 (0.74-1.24)

0.75

HCN1 981782

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

0.97 (0.87-1.09)

 

1.04 (0.87-1.24)

 

1.01 (0.82-1.23)

 

0.87 (0.63-1.20)

 
 

aa

 

0.86 (0.75-0.99)

 

0.84 (0.68-1.04)

 

1.00 (0.79-1.28)

 

0.87 (0.59-1.27)

 
 

Per Allele

0.50

0.93 (0.87-1.00)

0.04

0.92 (0.83-1.02)

0.13

1.00 (0.89-1.13)

0.98

0.93 (0.77-1.13)

0.46

ESR1 851987

AA

 

1

 

1

 

1

 

1

 
 

Aa

 

0.91 (0.82-1.02)

 

0.91 (0.78-1.06)

 

0.97 (0.80-1.17)

 

0.92 (0.69-1.22)

 
 

aa

 

0.88 (0.74-1.05)

 

0.92 (0.71-1.20)

 

0.83 (0.61-1.13)

 

0.76 (0.46-1.25)

 
 

Per Allele

0.89

0.93 (0.86-1.00)

0.06

0.94 (0.84-1.05)

0.29

0.93 (0.81-1.07)

0.30

0.89 (0.72-1.10)

0.28