Figure 1

Tissue explants taken from uterine fibroids show a nutlin-3 sensitivity as revealed by the increased expression of p21, BAX, and decreased expression of Ki-67 mRNA after 72 h incubation with nutlin-3 compared to the controls. Expression in the control explants (white bars, no treatment) was always set 100%. Ordinate: % change of expression compared to control. Hatched bars: 3 μM nutlin-3; grey bars: 10 μM nutlin-3. For tumor numbers below each group of bars rf. to Table 1. A: p21, B: BAX, C: Ki-67. Statistically significant increases (p21 and BAX) or decreases (Ki-67) are given by asterisks ( **, p < 0.01; ***, p < 0.001).