Figure 7From: Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium After incubation with nutlin-3 for six days, an increased expression of p21 as well as BAX and a decreased expression of Ki-67 compared to the controls was noted. Myometrium (C, not treated) was always set 100% and the expression of the corresponding fibroids refers to that value. A: expression of p21 mRNA, B: expression of BAX mRNA, C: expression of Ki-67 mRNA. For sample numbers refer to Table 1. Statistically significant increases (p21, and BAX) or decreases (Ki-67) are given by asterisks (*, p < 0.05; **, p < 0.01; ***, p < 0.001). n.d.: not detectable.Back to article page