Hazard ratios of RLX versus ALN for vertebral fracture and nonvertebral fracture in 1, 3, 5, 6 , 7 and 8-year cohorts, all patients (ALN served as the reference group). For nonvertebral fracture, hazard ratios were fitted based on marginal models which adjusted for the clustering of multiple events. For vertebral fracture, hazard ratios were fitted based on standard Cox models. P>0.05 in all models. ALN=alendronate; HR=hazard ratio; RLX=raloxifene.