Development of a diagnostic test set to assess agreement in breast pathology: practical application of the Guidelines for Reporting Reliability and Agreement Studies (GRRAS)

Table 2 Diagnostic Breast Pathology Assessment Tool Hierarchy (B-PATH) mapping categories for test set cases

Primary clinical diagnostic category	All diagnoses included in primary clinical diagnostic categories
I. Non-Proliferative*	Non-Proliferative only
I. Non-Proliferative*	Fibroadenoma
II. Proliferative changes without atypia	Usual ductal hyperplasia
	Columnar cell hyperplasia/columnar cell changes
	Sclerosing adenosis
	Radial Scar/complex sclerosing lesion
	Flat epithelial atypia
	Intraductal papilloma w/o atypia
III. Atypical ductal hyperplasia (ADH)	Atypical ductal hyperplasia
III. Atypical ductal hyperplasia (ADH)	Intraductal papilloma with atypia
IV. Ductal carcinoma in situ (DCIS)	Ductal carcinoma in situ
V. Invasive breast cancer	Invasive (ductal or lobular or other special type)

*For development of the test set, cases were categorized according to the highest ductal proliferative or malignant lesion present on the slide. When only lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (ALH) was present (n=2), we categorized cases as non-proliferative.

ISSN: 1472-6874