| Age-adjusted |  |  | Multivariable-adjusted |  |  |
---|---|---|---|---|---|---|
 | OR | 95% CI | p-value | OR | 95% CI | p-value |
Menarche | Â | Â | Â | Â | Â | Â |
<12Â years | 2.23 | 1.13-4.43 | 0.018 | 2.11 | 1.05-4.26 | 0.037 |
12-15Â years** | Â | Â | Â | Â | Â | Â |
>15Â years | 1.22 | 0.77-1.92 | 0.290 | 1.25 | 0.79-1.99 | 0.436 |
Parity | Â | Â | Â | Â | Â | Â |
0 | 1.37 | 0.83-2.26 | 0.195 | 1.41 | 0.83-2.38 | 0.186 |
1-2 | 1.01 | 0.73-1.41 | 0.397 | 1.02 | 0.73-1.42 | 0.383 |
>2** | Â | Â | Â | Â | Â | Â |
Age at menopause 1 | Â | Â | Â | Â | Â | Â |
≥ 50 years | 0.94 | 0.66-1.33 | 0.714 | 1.00 | 0.70-1.45 | 0.962 |
< 50 years** | Â | Â | Â | Â | Â | Â |
Time since menopause 1 | Â | Â | Â | Â | Â | Â |
> 15 years | 0.97 | 0.58-1.63 | 0.921 | 0.91 | 0.54-1.53 | 0.772 |
≤ 15 years** |  |  |  |  |  |  |
Duration of fertility 1 | Â | Â | Â | Â | Â | Â |
> 35.0Â years | 0.84 | 0.59-1.20 | 0.339 | 0.87 | 0.61-1.25 | 0.449 |
≤ 35.0 years** |  |  |  |  |  |  |
Current use of HRT | Â | Â | Â | Â | Â | Â |
Yes | 0.78 | 0.49-1.24 | 0.294 | 0.79 | 0.49-1.26 | 0.316 |
No** | Â | Â | Â | Â | Â | Â |
Ever use of HRT | Â | Â | Â | Â | Â | Â |
Yes | 0.60 | 0.44-0.81 | 0.001 | 0.62 | 0.45-0.86 | 0.003 |
No** | Â | Â | Â | Â | Â | Â |
Ever use of OC | Â | Â | Â | Â | Â | Â |
Yes | 1.25 | 0.89-1.78 | 0.203 | 1.34 | 0.93-1.90 | 0.125 |
No** | Â | Â | Â | Â | Â | Â |
Hysterectomy | Â | Â | Â | Â | Â | Â |
Yes | 0.84 | 0.61-1.16 | 0.285 | 0.83 | 0.60-1.16 | 0.284 |
No** | Â | Â | Â | Â | Â | Â |
Bilateral oophorectomy | Â | Â | Â | Â | Â | Â |
Yes | 0.68 | 0.37-1.26 | 0.221 | 0.65 | 0.35-1.22 | 0.178 |
No** | Â | Â | Â | Â | Â | Â |
Hot flashes | Â | Â | Â | Â | Â | Â |
Yes | 0.93 | 0.67-1.30 | 0.664 | 0.90 | 0.64-1.26 | 0.535 |
No** | Â | Â | Â | Â | Â | Â |
Depressed mood | Â | Â | Â | Â | Â | Â |
Yes | 1.16 | 0.84-1.60 | 0.367 | 1.15 | 0.83-1.59 | 0.396 |
No** | Â | Â | Â | Â | Â | Â |