A case of a large solitary fibrous tumour of the uterine cervix

BMC Women's Health

Table 1 Cases of solitary fibrous tumours of the uterine cervix reported in the literature

Author	Patient’s age (years)	Maximal diameter of tumour (cm)	Immunohistochemical profile	Symptoms	Treatment	Follow-up	Outcome
Hasegawa et al. [3, 5]	78	6	(+): MIB1-LI 0.5%, bcl-2, CD34 (-): S100, CK, desmin, CD31, α-SMA, EMA	Abnormal vaginal bleeding	Excision (not specified)	11 years	NR
Sidebotham et al. [4]	14	1.7	(+): MIB1-LI 5%, CD34, patchy (+): S100, CD68, focally (+): ER, PR, SMA, (-): bcl-2, desmin, myogenin, WT-1, CD99, CD1a, HMB-45, alk	Abnormal vaginal bleeding	Abdominal radical trachelectomy	2 weeks	Alive, NR
Rahimi et al. [2]	68	1.7	(+): vim, CD99, CD34, bcl-2, ER, PR, β-catenin, (-): EMA, S100, factor XIIIa, CKAE1/AE3, caldesmon, desmin, CD31, SMA	None	Robotic assisted radical hysterectomy*	NA	NA
Current case	45	16	(+): CD34, bcl-2, vim, focally (+): SMA, desmin, (-): S100, CKAE1/AE3	Abnormal vaginal bleeding, low abdominal pain	Radical hysterectomy	8 months	Alive, NR

(+) – positive immunostaining, MIB1-LI – MIB1 labeling index, bcl-2 – B-cell lymphoma 2, (-) – negative immunostaining, S100 – S100 protein, CK – cytokeratin, α-SMA – α-smooth muscle actin, EMA - epithelial membrane antigen, NR – no recurrence, ER- estrogen receptor, PR – progesterone receptor, SMA – smooth muscle actin, WT-1 – Wilm’s tumour gene, CD1a – CD1a molecule, HMB-45 – human melanoma black monoclonal antibody, alk – anaplastic lymphoma kinase, vim – vimentin, NA – data not available, CKAE1/AE3 – cytokeratin AE1/AE3, *the solitary fibrous tumour accompanied an invasive cervical cancer. All reported cases had benign histology.

ISSN: 1472-6874