Health related quality of life in patients in dialysis after renal graft loss and effect of gender

Table 3 Associations of explanatory variables on dimensions of HRQOL in female and male dialysis patients

FEMALE GENDER (n = 90)	Effect kidney disease			Physical function			Cognitive function			General health
	R² = 0.29, p <0.001			R²= 0.27, p < 0.001			R²= 0.15, p = 0.03			R²= 0.18, p = 0.009
	β	t	p	β	t	p	β	t	p	β	t	p
Graft loss yes/no	-14.55	-2.49	0.015	-17.8	-2.59	0.01	-11.65	-2.41	0.018	-12.38	-2.04	0.045
Age +1 year	0.42	2.70	0.009	-0.50	-2.69	0.009	0.20	1.55	0.13	0.21	1.31	0.20
Comorbidity* +1 point	-4.75	-3.34	0.001	-5.85	-3.51	0.001	-1.22	-1.03	0.31	-4.28	-2.89	0.005
BMI^† ≥ 25.0 kg/m² yes/no	6.69	1.42	0.16	-0.45	-0.08	0.94	5.43	1.40	0.17	7.76	1.59	0.12
Dialysis vintage^‡ ≥ 10 months yes/no	-2.56	-0.52	0.61	0.54	-0.09	0.93	0.35	0.09	0.93	3.91	0.77	0.45
Nephrosclerosis yes/no	-8.83	-1.40	0.17	-10.66	-1.44	0.15	-9.39	-1.79	0.08	-12.50	-1.90	0.06
MALE GENDER (n = 197)	Effect kidney disease			Physical function			Cognitive function			General health
	R ² = 0.17, p < 0.001			R ² = 0.23 p < 0.001			R ² = 0.06 p = 0.11			R ² = 0.16, p<0.001
	β	t	p	β	t	p	β	t	p	β	t	p
Graft loss yes/no	2.33	0.59	0.56	3.04	0.55	0.58	2.63	0.70	0.49	-1.67	-0.37	0.71
Age +1 year	0.38	4.28	<0.001	-0.49	-3.98	<0.001	0.25	2.93	0.004	0.24	2.42	0.016
Comorbidity* +1 point	-2.12	-2.74	0.007	-4.03	-3.74	<0.001	0.34	0.46	0.65	-4.04	-4.63	>0.001
BMI^† ≥ 25.0 kg/m² yes/no	7.46	2.84	0.005	-0.08	-0.02	0.98	1.49	0.60	0.55	3.62	1.22	0.23
Dialysis vintage^‡ ≥ 10 months yes/no	-5.83	-2.19	0.03	-8.52	-2.30	0.02	-1.88	-0.75	0.46	-9.08	-3.03	0.003
Nephrosclerosis yes/no	-1.24	-0.42	0.66	3.32	0.81	0.42	-3.20	-1.15	0.25	-1.45	-0.44	0.66

Multiple regression analyses. Scores 0 -100, higher number indicating better QOL.
*Charlson comorbidity index without age; ^† Body mass index, dichotomized above or below 25.0 kg/m².
^‡Time in dialysis dichotomized with above or below the median value of 10 months.
Albumin, CRP, systolic blood pressure and cholesterol were not significant in univariate analyses, and therefore not included.

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