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Table 4 HRs and 95% CIs of total, boiled and filtered coffee consumption stratified by BMI and smoking status in 97 926 postmenopausal NOWAC Study participants

From: High coffee consumption and different brewing methods in relation to postmenopausal endometrial cancer risk in the Norwegian Women and Cancer Study: a population-based prospective study

 

No of cups

Age-adjusted HR, CI 95%a

Multivariate-adjusted HR, CI 95%b

  

Total coffee

Boiled coffee

Filtered coffee

Total coffee

Boiled coffee

Filtered coffee

BMI < 25

≤ 1

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

 

2-3

0.93 (0.63-1.38)

0.88 (0.53-1.47)

1.29 (0.93-1.79)

0.96 (0.65-1.42)

0.87 (0.52-1.46)

1.25 (0.90-1.74)

 

4-7

0.78 (0.53-1.16)

0.88 (0.53-1.44)

1.05 (0.75-1.49)

0.86 (0.58-1.29)

0.97 (0.59-1.60)

1.11 (0.78-1.57)

 

≥ 8

0.54 (0.31-0.96)

0.50 (0.19-1.36)

0.57 (0.29-1.14)

0.65 (0.36-1.17)

0.59 (0.22-1.63)

0.66 (0.33-1.32)

p for trend

 

0.009

0.13

0.39

0.008

0.31

0.77

BMI ≥ 25

≤ 1

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

 

2-3

0.82 (0.57-1.17)

1.26 (0.85-1.85)

0.79 (0.58-1.09)

0.83 (0.58-1.19)

1.22 (0.83-1.80)

0.78 (0.57-1.08)

 

4-7

0.72 (0.51-1.02)

1.13 (0.77-1.67)

0.72 (0.51-1.02)

0.78 (0.55-1.12)

1.21 (0.82-1.79)

0.83 (0.60-1.13)

 

≥ 8

0.33 (0.18-0.61)

0.33 (0.10-1.02)

0.40 (0.19-0.83)

0.39 (0.21-0.73)

0.39 (0.12-1.23)

0.46 (0.22-0.96)

p for trend

 

0.0005

0.44

0.01

0.009

0.79

0.05

Never smokers

≤ 1

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

 

2-3

1.01 (0.7-1.44)

1.09 (0.72-1.67)

1.15 (0.85-1.57)

1.05 (0.74-1.51)

1.07 (0.70-1.62)

1.19 (0.87-1.62)

 

4-7

0.97 (0.67-1.41)

0.95 (0.57-1.58)

0.08 (0.76-1.53)

0.97 (0.67-1.42)

0.91 (0.55-1.53)

1.08 (0.76-1.53)

 

≥ 8

0.54 (0.23-1.26)

0.36 (0.05-2.52)

0.67 (0.25-1.83)

0.49 (0.21-1.16)

0.33 (0.05-2.33)

0.63 (0.23-1.72)

p for trend

 

0.41

0.59

0.99

0.26

0.44

0.94

Former smokers

≤ 1

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

 

2-3

0.75 (0.47-1.19)

1.05 (0.59-1.86)

0.69 (0.45-1.05)

0.76 (0.47-1.21)

1.04 (0.58-1.85)

0.70 (0.46-1.07)

 

4-7

0.76 (0.48-1.21)

1.79 (1.12-2.85)

0.79 (0.52-1.18)

0.74 (0.46-1.18)

1.69 (1.06-2.72)

0.77 (0.51-1.16)

 

≥ 8

0.59 (0.29-1.20)

0.25 (0.03-1.76)

0.66 (0.30-1.45)

0.57 (0.28-1.15)

0.23 (0.03-1.67)

0.64 (0.29-1.42)

p for trend

 

0.09

0.67

0.19

0.06

0.83

0.18

Current smokers

≤ 1

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

1.0 (ref)

 

2-3

0.73 (0.37-1.45)

1.16 (0.56-2.41)

1.04 (0.60-1.78)

0.76 (0.38-1.52)

1.16 (0.56-2.42)

1.04 (0.60-1.79)

 

4-7

0.61 (0.32-1.15)

0.76 (0.39-1.48)

0.93 (0.58-1.50)

0.64 (0.34-1.21)

0.77 (0.39-1.50)

0.96 (0.59-1.55)

 

≥ 8

0.36 (0.17-0.79)

0.69 (0.28-1.73)

0.40 (0.17-0.95)

0.37 (0.17-0.81)

0.69 (0.28-1.73)

0.40 (0.17-0.95)

p for trend

 

0.009

0.30

0.12

0.01

0.30

0.13

  1. aBasic model that was adjusted for age. bMultivariate model that was adjusted for parity, smoking status, BMI, duration of OC and HRT use. Abbreviations: HR Hazard ratio, CI Confidence interval, BMI Body mass index, NOWAC Norwegian Women and Cancer, OC Oral contraceptives, HRT Hormone replacement therapy.
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