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Table 1 Study design and demographic data

From: A systematic review of effectiveness and safety of different regimens of levonorgestrel oral tablets for emergency contraception

Study (year) [ref] Country Population characteristics Study design
   No. of subjects Age (years) Type of trial Dose Dose frequency
Arowojolu et al., (2002) [30] Nigeria 1160 19-35 Prospective comparative study 0.75 mg & 1.5 mg Once & two split doses 12 h apart
Croxatto et al., (2004) [33] Chile, Dominican Republic 58 18-40 Two-center, randomized, double-blind, placebo-controlled study 0.75 mg Two doses given 12 h apart, or a single dose
Dada et al., (2010) [31] Nigeria 3022 20-33 Randomized, controlled, double-blind, multicentre, non-inferiority trial 0.75 mg & 1.5 mg Two doses, 12 h apart vs. a single dose
Durand et al., (2001) [18] Mexico 45 29-35 Randomized, comparative study 0.75 mg Two doses taken 12 h apart, at 0 h & after 48 h
Durand et al., (2005) [34] Mexico 30 29-35 Randomized, comparative study 0.75 mg Two doses taken 12 h apart, at 0 h & after 48 h
Gainer et al., (2007) [28] Chile 12 18-32 1.5 mg Once
Hapangama et al., (2001) [19] Scotland 12 26-41 Prospective, randomized, double-blind, crossover study 0.75 mg Two doses given 12 h apart
Johansson et al., (2002) [23] Dominican Republic 5 18-45 Randomized, comparative study 0.75 mg & 1.5 mg Once, two doses given 12 h apart, two doses given 24 h apart
Kook et al., (2002) [24] USA 16 19-44 Open label study 0.75 mg Twice, taken 12 h apart
Ngai et al., (2005) [32] China 2071 20-34 Double-blind, randomized trial 0.75 mg Every 24 h & every 12 h
Noé et al., (2010) [35] Chile 388 18-38 Prospective, open-label, single-drug, single dose, uncontrolled clinical trial 1.5 mg Once
Raymond et al., (2006) [36] USA 120 18-38 Case-series study 1.5 mg Once
Sambol et al., (2006) [29] USA 22 13-16 Prospective, single-period, single center, open-label clinical trial 0.75 mg Once
Tremblay et al., (2001) [25] South Africa 24 18-26 Open, observer-blind, randomized study 0.75 mg Once, two doses given 12 h apart, two doses given 24 h apart