Study (year) | Dose | Pkparameters | Side effects | |||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | AUC0–12(ng-h/ml) | AUC0–24(ng-h/ml) | AUC0-t(ng-h/ml) | AUC0-∞(ng-h/ml) | Cmax(ng/ml) | tmax(h) | Kel(1/h) | t1/2(h) |  |
Gainer et al., (2007) [28] | 1.5Â mg | 28.6 | 45.0 | 252.8 | 262.6 | 15.4 | 2.0 | ---- | 29.3 | ---- |
Johansson et al., (2002) [23] | 0.75Â mg & 1.5Â mg | A:49.9 | A:81.3 | A:139.5 | ---- | A:7.9 | A:1.8 | ---- | A:43.7 | Nausea, sleepiness, headache. |
B:51.9 | B:73.2 | B:136.0 | Â | B:8.4 | B:1.4 | Â | B:32.0 | |||
C:88.8 | C:130.8 | C:290.9 | Â | C:12.4 | C:2.5 | Â | C:43.3 | |||
Kook et al., (2002) [24] | 0.75Â mg | ---- | ---- | 111.8 | 123.1 | 14.1 | 1.63 | 0.030 | 24.4 | Menstrual irregularity |
Sambol et al., (2006) [29] | 0.75Â mg | ---- | ---- | ---- | 86.1 | 6.72 | 1.43 | ---- | 21.2 | Headaches, dizziness, nausea, cramps |
Tremblay et al., (2001) [25] | 0.75Â mg | ---- | ---- | ---- | 133.02 | ---- | 2.27 | 0.042 | 21.72 | ---- |