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Table 2 Pharmacokinetic comparison of different dosage regimens of levonorgestrel

From: A systematic review of effectiveness and safety of different regimens of levonorgestrel oral tablets for emergency contraception

Study (year) Dose Pkparameters Side effects
   AUC0–12(ng-h/ml) AUC0–24(ng-h/ml) AUC0-t(ng-h/ml) AUC0-∞(ng-h/ml) Cmax(ng/ml) tmax(h) Kel(1/h) t1/2(h)  
Gainer et al., (2007) [28] 1.5 mg 28.6 45.0 252.8 262.6 15.4 2.0 ---- 29.3 ----
Johansson et al., (2002) [23] 0.75 mg & 1.5 mg A:49.9 A:81.3 A:139.5 ---- A:7.9 A:1.8 ---- A:43.7 Nausea, sleepiness, headache.
B:51.9 B:73.2 B:136.0   B:8.4 B:1.4   B:32.0
C:88.8 C:130.8 C:290.9   C:12.4 C:2.5   C:43.3
Kook et al., (2002) [24] 0.75 mg ---- ---- 111.8 123.1 14.1 1.63 0.030 24.4 Menstrual irregularity
Sambol et al., (2006) [29] 0.75 mg ---- ---- ---- 86.1 6.72 1.43 ---- 21.2 Headaches, dizziness, nausea, cramps
Tremblay et al., (2001) [25] 0.75 mg ---- ---- ---- 133.02 ---- 2.27 0.042 21.72 ----
  1. AUC0-t: Area under the plasma concentration time curve calculated by the trapezoidal rule from time 0 until the last time point.
  2. AUC0-∞: Area under the plasma concentration time curve corrected for the previous administration and extrapolated to infinity.
  3. A: One tablet of 0.75 mg levonorgestrel at time −12 h and one tablet at time 0.
  4. B: One tablet of 0.75 mg levonorgestrel at time 0.
  5. C: One tablet of 0.75 mg levonorgestrel at time −24 h and one tablet at time 0.