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Table 2 Odds ratios (OR) for premenstrual syndrome by blood levels of vitamin D-related biomarkers, NHS2 PMS Sub-study

From: Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study

Factor Cases Controls Unadjusted OR (95% CI) MV adjusted OR* (95% CI)
25-hydroxyvitamin D     
Deficiency vs. Sufficiency     
< 50 nmol/L 86 90 1.00 1.00
≥ 50 nmol/L 315 311 1.07 (0.75 – 1.53) 1.14 (0.77 – 1.68)
Quintiles (median, nmol/L)     
Q1 (42.4) 72 81 1.00 1.00
Q2 (53.5) 76 79 1.10 (0.70 – 1.74) 1.02 (0.56 – 1.84)
Q3 (62.6) 72 81 1.03 (0.65 – 1.63) 1.23 (0.67 – 2.29)
Q4 (73.6) 96 79 1.44 (0.90 – 2.30) 1.25 (0.65 – 2.41)
Q5 (91.6) 85 81 1.26 (0.79 – 2.02) 1.16 (0.60 – 2.41)
Per 10 nmol/L change 401 401 1.05 (0.97 – 1.13) 1.04 (0.93 – 2.25)
Total calcium     
Quintiles (median, mg/dL)     
Q1 (9.3) 79 79 1.00 1.00
Q2 (9.6) 83 83 1.00 (0.65 – 1.55) 1.13 (0.63 – 2.02)
Q3 (9.7) 90 101 0.91 (0.59 – 1.39) 0.91 (0.52 – 1.60)
Q4 (9.9) 67 63 1.09 (0.67 – 1.77) 1.28 (0.69 – 2.37)
Q5 (10.2) 82 75 1.12 (0.69 – 1.80) 1.03 (0.55 – 1.94)
Per 1 mg/dL change 401 401 1.11 (0.74 – 1.67) 1.18 (0.70 – 2.00)
iPTH     
Quintiles (median, pg/mL)     
Q1 (19.4) 81 80 1.00 1.00
Q2 (23.8) 59 79 0.72 (0.46 – 1.15) 0.70 (0.38 – 1.27)
Q3 (28.5) 96 79 1.21 (0.79 – 1.85) 1.50 (0.85 – 2.64)
Q4 (34.5) 80 80 1.00 (0.64 – 1.55) 1.16 (0.65 – 2.08)
Q5 (46.9) 85 83 1.01 (0.66 – 1.55) 0.89 (0.50 – 1.58)
Per 10 pg/mL change 401 401 1.01 (0.89 – 1.13) 0.93 (0.78 – 1.10)
  1. *Multivariable (MV) OR from conditional logistic regression adjusted for race/ethnicity, geographic region, BMI, physical activity, alcohol intake, smoking status, number of moles on leg, oral contraceptive use, maternal education, antidepressant use, significant childhood trauma, and vitamin B6 intake. Each biomarker adjusted for the others (continuous levels).