Table 2 Odds ratios (OR) for premenstrual syndrome by blood levels of vitamin D-related biomarkers, NHS2 PMS Sub-study

25-hydroxyvitamin D

Deficiency vs. Sufficiency

< 50 nmol/L

86

90

1.00

1.00

≥ 50 nmol/L

315

311

1.07 (0.75 – 1.53)

1.14 (0.77 – 1.68)

Quintiles (median, nmol/L)

Q1 (42.4)

72

81

1.00

1.00

Q2 (53.5)

76

79

1.10 (0.70 – 1.74)

1.02 (0.56 – 1.84)

Q3 (62.6)

72

81

1.03 (0.65 – 1.63)

1.23 (0.67 – 2.29)

Q4 (73.6)

96

79

1.44 (0.90 – 2.30)

1.25 (0.65 – 2.41)

Q5 (91.6)

85

81

1.26 (0.79 – 2.02)

1.16 (0.60 – 2.41)

Per 10 nmol/L change

401

401

1.05 (0.97 – 1.13)

1.04 (0.93 – 2.25)

Total calcium

Quintiles (median, mg/dL)

Q1 (9.3)

79

79

1.00

1.00

Q2 (9.6)

83

83

1.00 (0.65 – 1.55)

1.13 (0.63 – 2.02)

Q3 (9.7)

90

101

0.91 (0.59 – 1.39)

0.91 (0.52 – 1.60)

Q4 (9.9)

67

63

1.09 (0.67 – 1.77)

1.28 (0.69 – 2.37)

Q5 (10.2)

82

75

1.12 (0.69 – 1.80)

1.03 (0.55 – 1.94)

Per 1 mg/dL change

401

401

1.11 (0.74 – 1.67)

1.18 (0.70 – 2.00)

iPTH

Quintiles (median, pg/mL)

Q1 (19.4)

81

80

1.00

1.00

Q2 (23.8)

59

79

0.72 (0.46 – 1.15)

0.70 (0.38 – 1.27)

Q3 (28.5)

96

79

1.21 (0.79 – 1.85)

1.50 (0.85 – 2.64)

Q4 (34.5)

80

80

1.00 (0.64 – 1.55)

1.16 (0.65 – 2.08)

Q5 (46.9)

85

83

1.01 (0.66 – 1.55)

0.89 (0.50 – 1.58)

Per 10 pg/mL change

401

401

1.01 (0.89 – 1.13)

0.93 (0.78 – 1.10)