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Table 1 Trial details

From: Rofecoxib for dysmenorrhoea: meta-analysis using individual patient data

Trial ID Study drug and dose, number of women Design Observations after 8 hrs Quality score Validity score
38 49 women
Rofecoxib 25 mg
Rofecoxib 50 mg
Ibuprofen 400 mg
Placebo
Single oral dose, parallel 3 menstrual cycles 12, 24 5/5 ≥13/16
55 60 women
Rofecoxib 50 mg then 25 mg as required
Naproxen sodium 550 mg every 12 hrs
Placebo
Oral. Multiple dose study with single dose efficacy data, multiple dose adverse events Cross-over, 1 of 6 drug sequences 3 menstrual cycles 12 hour obervations after a single dose in a three-day study 5/5 ≥13/16
56 122 women
Rofecoxib 50 mg as required
Rofecoxib 50 mg then 25 mg as required
Naproxen sodium 550 mg every 12 hrs
Placebo
Oral. Multiple dose study with single dose efficacy data, multiple dose adverse events Cross-over, 1 of 4 drug sequences 4 menstrual cycles 12 hour obervations after a single dose in a three-day study 5/5 ≥13/16