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Table 1 Characteristics of the participants

From: Correlation of breast cancer risk factors with HER-2/neu protein overexpression according to menopausal and estrogen receptor status

Factors Cases N = 384 n(%) Controls N = 566 n(%) OR1 (95% CI) OR2 (95% CI)
Age at interview     
≤ 50 years 138(36) 178(31) 1.00  
>50 years 246(64) 388(69) 0.82(0.62–1.08) NS
Area of residence     
rural 189(49) 292(52) 1.00  
urban 195(51) 274(48) 0.91(0.70–1.18) NS
Menopausal status     
Pre/perimenopausal 134(35) 170(30) 1.00  
Postmenopausal 250(65) 396(70) 0.80(0.60–1.06) NS
Age at menopause 3     
≤ 50 years 144(59) 252(64) 1.00  
>50 years 102(41) 140(36) 1.28(0.92–1.77) NS
Age of menarche     
≤ 12 years 155(40) 150(27) 1.86(1.41–2.45)  
>12 years 229(60) 412(73) 1.00 NS
Use of oral contraceptives     
no 341(89) 548(97) 1.00 1.00
yes 43(11) 18(3) 3.84(2.18–6.77) 4.40(1.46–13.28)
Use of HRT 3     
no 231(92) 393(99) 1.00 1.00
yes 19(8) 3(1) 10.78(3.15–36.81) 7.34(2.03–26.53)
First degree family history     
no 341(89) 522(92) 1.00  
yes 43(11) 44(8) 1.5(0.96–2.33) NS
Age at first full pregnancy     
<23 years 106(35) 239(50) 1.00 1.00
≥ 23 years 197(65) 242(50) 1.84(1.37–2.47) 1.91(1.29–2.83)
Parity     
nulliparous 79(20) 78(14) 1.00  
1–2 175(46) 255(45) 0.68(0.47–0.98) NS
3 plus 130(34) 233(41) 0.55(0.38–0.80) NS
Abortion or miscarriage     
no 183(57) 247(50) 1.00 1.00
yes 138(43) 248(50) 0.75(0.57–0.99) 0.56(0.38–0.82)
Lactation     
no 67(22) 84(17) 1.00  
yes 238(78) 404(82) 0.74(0.52–1.06) NS
Medication to suppress lactation     
no 273(90) 438(90) 1.00  
yes 31(10) 50(10) 0.99(0.62–1.60) NS
Radiation to the chest     
no 372(97) 550(97) 1.00  
yes 12(3) 16(3) 1.11(0.52–2.37) NS
Body mass index     
≤ 29 kg/m2 282(74) 498(88) 1.00 1.00
>29 kg/m2 97(26) 68(12) 2.52(1.79–3.55) 3.13 (2.03–4.84)
Benign breast disease     
no 315(82) 472(83) 1.00  
yes 69(18) 94(17) 1.10(0.78–1.55) NS
  1. 1 Adjusted for age. -2 Adjusted for age, residence, menopausal status, menopausal age, menarche age, use of OC, use of HRT, first degree family history, age at first full pregnancy, parity, abortion, lactation, medication to suppress lactation, radiation to the chest, body mass index and benign breast disease. -3Postmenopausal women only.
  2. NS: non significant multivariate OR. Bold types: statistically significant values.