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Table 1 Characteristics of the participants

From: Correlation of breast cancer risk factors with HER-2/neu protein overexpression according to menopausal and estrogen receptor status

Factors

Cases N = 384 n(%)

Controls N = 566 n(%)

OR1 (95% CI)

OR2 (95% CI)

Age at interview

    

≤ 50 years

138(36)

178(31)

1.00

 

>50 years

246(64)

388(69)

0.82(0.62–1.08)

NS

Area of residence

    

rural

189(49)

292(52)

1.00

 

urban

195(51)

274(48)

0.91(0.70–1.18)

NS

Menopausal status

    

Pre/perimenopausal

134(35)

170(30)

1.00

 

Postmenopausal

250(65)

396(70)

0.80(0.60–1.06)

NS

Age at menopause 3

    

≤ 50 years

144(59)

252(64)

1.00

 

>50 years

102(41)

140(36)

1.28(0.92–1.77)

NS

Age of menarche

    

≤ 12 years

155(40)

150(27)

1.86(1.41–2.45)

 

>12 years

229(60)

412(73)

1.00

NS

Use of oral contraceptives

    

no

341(89)

548(97)

1.00

1.00

yes

43(11)

18(3)

3.84(2.18–6.77)

4.40(1.46–13.28)

Use of HRT 3

    

no

231(92)

393(99)

1.00

1.00

yes

19(8)

3(1)

10.78(3.15–36.81)

7.34(2.03–26.53)

First degree family history

    

no

341(89)

522(92)

1.00

 

yes

43(11)

44(8)

1.5(0.96–2.33)

NS

Age at first full pregnancy

    

<23 years

106(35)

239(50)

1.00

1.00

≥ 23 years

197(65)

242(50)

1.84(1.37–2.47)

1.91(1.29–2.83)

Parity

    

nulliparous

79(20)

78(14)

1.00

 

1–2

175(46)

255(45)

0.68(0.47–0.98)

NS

3 plus

130(34)

233(41)

0.55(0.38–0.80)

NS

Abortion or miscarriage

    

no

183(57)

247(50)

1.00

1.00

yes

138(43)

248(50)

0.75(0.57–0.99)

0.56(0.38–0.82)

Lactation

    

no

67(22)

84(17)

1.00

 

yes

238(78)

404(82)

0.74(0.52–1.06)

NS

Medication to suppress lactation

    

no

273(90)

438(90)

1.00

 

yes

31(10)

50(10)

0.99(0.62–1.60)

NS

Radiation to the chest

    

no

372(97)

550(97)

1.00

 

yes

12(3)

16(3)

1.11(0.52–2.37)

NS

Body mass index

    

≤ 29 kg/m2

282(74)

498(88)

1.00

1.00

>29 kg/m2

97(26)

68(12)

2.52(1.79–3.55)

3.13 (2.03–4.84)

Benign breast disease

    

no

315(82)

472(83)

1.00

 

yes

69(18)

94(17)

1.10(0.78–1.55)

NS

  1. 1 Adjusted for age. -2 Adjusted for age, residence, menopausal status, menopausal age, menarche age, use of OC, use of HRT, first degree family history, age at first full pregnancy, parity, abortion, lactation, medication to suppress lactation, radiation to the chest, body mass index and benign breast disease. -3Postmenopausal women only.
  2. NS: non significant multivariate OR. Bold types: statistically significant values.