Figure 5

A-D. Category III. Atypical hyperplasia. NAF from a 65-year-old Caucasian woman with a family history of breast cancer and an elevated Gail index of 3.0%. NAF analysis reveals moderate to severe cytologic abnormalities including distinct nuclear enlargement, increasing nuclear to cytoplasmic ratio, irregular nuclear borders, and nuclear variation. The chromatin is coarsely granular and there are prominent chromocenters. While the cells are distributed mainly in groups with occasional papillary formations, there are also increased numbers of single atypical cells (arrow-A). After the Category III findings, a ductal biopsy was performed that was found to be benign. A breast biopsy six months later showed DCIS. Pap 100X.