Figure 6

A-D. Category III. Atypical hyperplasia. NAF from a 45-year-old Caucasian woman with a Gail index of 1.1% and no significant medical history. NAF analysis reveals moderate to severe cytologic abnormalities including distinct nuclear enlargement, increasing nuclear to cytoplasmic ratio, irregular nuclear borders, and nuclear variation. The chromatin is coarsely granular and there are prominent chromocenters. Follow-up bilateral biopsies showed LCIS in the right breast, and hyperplastic changes in the left. The changes depicted in these micrographs are not specific for either of those entities and may have originated from other areas of atypia (e.g., DCIS) that was not sampled by the biopsies. Pap 100X.