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Figure 1 | BMC Women's Health

Figure 1

From: Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

Figure 1

TRPV1-immunoreactive nerve fibres in breast skin. (A) Normal, control skin : TRPV1-immunoreactive nerve fibres (small arrows) in the sub-epidermis. (B) Painful skin (macromastia patient): intra-epidermal, TRPV1-immunoreactive nerve fibre (arrow) deriving from a large, sub-epidermal fascicle and extending to the stratum corneum. (Ci) Painful skin (breast reconstruction patient): TRPV1-immunoreactive intra-epidermal fibres passing along the junction between the epidermis and stratum corneum (Cii-enlarged area from Ci). (Di) Painful skin (macromastia patient): multiple branching, TRPV1-immunoreactive intra-epidermal nerve fibres (arrows) extending to the stratum corneum (Dii-enlarged area from Di). Large double arrows indicate relative epidermal thickness. Scale bars: A, B, C(i), D(i) = 50 μm; C(ii), D(ii) = 10 μm.

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