Table 3 Human and rat orthologous genes differentially expressed in human uterine fibroids and E2-responsive in the rat uterus.
Gene | Symbol | Uterine fibroids | 1-Day | 5-Week | Previous reports on E2 regulation | ||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Ha | Ta | Wa | ovx | E2 | ovx | E2 | Â |
prostaglandin E receptor 3 (subtype EP3) | PTGER3 | Â | -4.2 | -2.8 | 1.8 | -1.8 | 1.6 | -1.7 | None |
transforming growth factor, beta receptor II (70/80kDa) | TGFBR2 | -1.8 | -2.0 | Â | 3.3 | -3.2 | 5.4 | -15.6 | None |
Purkinje cell protein 4 | PCP4 | 4.9 | 8.2 | Â | NS | NS | -1.4 | 2.4 | None |
calcitonin receptor-like receptor | CALCRL | -2.1 | Â | -1.7 | 1.9 | -1.7 | 1.2 | -1.3 | [35] [34] |
aldehyde dehydrogenase 1 family, member A1 | ALDH1A1 | -3.5 | -8.0 | -3.8 | 7.7 | -9.0 | 4.5 | -4.4 | [28] [29] |
annexin A1 | ANXA1 | -4.1 | -4.3 | Â | -1.4 | 1.6 | NS | NS | [33] |
cellular retinoic acid binding protein 2 | CRABP2 | 3.1 | 5.1 | 2.6 | -23.1 | 37.6 | NS | NS | [28] [29] |
prostaglandin D2 synthase 21kDa (brain) | L-PTGDS | -2.0 | -3.5 | -2.1 | 2.0 | -2.3 | 1.8 | -2.0 | [30, 31] [32] |
nuclear receptor subfamily 4, group A, member 1 | NR4A1 | -3.7 | -3.8 | Â | NS | NS | -1.8 | 5.4 | [37] [64] |
proteolipid protein 1 | PLP1 | 4.8 | 12.1 | Â | 1.3 | -1.5 | 1.3 | -1.3 | None |
ribonuclease, RNase A family, 4 | RNASE4 | -2.0 | -3.4 | Â | NS | NS | 3.5 | -4.3 | None |
insulin-like growth factor 2 (somatomedin A) | IGF2 | Â | 16.8 | 2.6 | NS | NS | 2.2 | -1.6 | Contradictory to [38] [40] [39] |