Table 2 Proportion of women reporting different symptoms in each arm of the EPHT Trial over time* and the effect of hormone therapy on symptom reporting
From: Symptom reporting and quality of life in the Estonian Postmenopausal Hormone Therapy Trial
Symptom | Non- blind HT (%) | Non- treatment (%) | Blind HT (%) | Placebo (%) | OR (95% CI) |
|---|---|---|---|---|---|
Hot flushes | |||||
recruitment | 43.4 | 41.1 | 46.2 | 48.4 | 0.20 (0.14–0.28) |
2nd year | 10.8 | 22.9 | 9.1 | 26.2 | |
final | 14.6 | 23.6 | 13.1 | 22.5 | |
Sweating | |||||
recruitment | 50.0 | 43.5 | 46.2 | 47.2 | 0.56 (0.44–0.72) |
2nd year | 23.9 | 32.4 | 22.9 | 32.8 | |
final | 26.4 | 31.8 | 24.0 | 31.4 | |
Trouble sleeping | |||||
recruitment | 31.4 | 30.3 | 30.2 | 34.3 | 0.66 (0.52–0.84) |
2nd year | 25.6 | 31.1 | 24.9 | 32.0 | |
final | 34.1 | 36.2 | 31.3 | 33.3 | |
Depression | |||||
recruitment | 27.1 | 27.2 | 23.4 | 21.0 | 0.81 (0.60–1.08) |
2nd year | 19.9 | 21.1 | 19.2 | 22.8 | |
final | 21.6 | 23.6 | 18.9 | 19.3 | |
Anxiety | |||||
recruitment | 34.4 | 36.1 | 34.6 | 33.2 | 0.93 (0.73–1.19) |
2nd year | 27.1 | 25.7 | 28.3 | 27.8 | |
final | 27.3 | 29.5 | 25.2 | 25.2 | |
Backache | |||||
recruitment | 40.2 | 40.0 | 42.1 | 36.0 | 1.15 (0.96–1.38) |
2nd year | 38.7 | 37.0 | 35.7 | 37.3 | |
final | 45.4 | 37.2 | 39.5 | 35.6 | |
Stiffness/aches in joints | |||||
recruitment | 57.5 | 54.5 | 56.3 | 54.2 | 0.97 (0.82–1.15) |
2nd year | 50.3 | 56.4 | 50.8 | 57.0 | |
final | 57.5 | 56.5 | 54.4 | 56.5 | |
Chronic fatigue | |||||
recruitment | 55.5 | 53.9 | 51.7 | 49.0 | 1.11 (0.90–1.35) |
2nd year | 52.8 | 51.6 | 47.5 | 49.4 | |
final | 55.3 | 49.5 | 47.7 | 49.3 | |
Headache | |||||
recruitment | 39.1 | 33.3 | 35.1 | 38.8 | 1.08 (0.76–1.54) |
2nd year | 34.1 | 30.1 | 33.3 | 32.4 | |
final | 35.7 | 30.9 | 35.3 | 33.3 | |
Dizzy spells | |||||
recruitment | 26.6 | 23.3 | 21.1 | 24.7 | 0.97 (0.74–1.28) |
2nd year | 18.7 | 22.3 | 21.2 | 19.6 | |
final | 19.4 | 23.0 | 19.5 | 16.7 | |
Diarrhoea or constipation | |||||
recruitment | 26.4 | 26.6 | 21.2 | 21.7 | 0.99 (0.75–1.30) |
2nd year | 24.8 | 20.2 | 18.6 | 19.9 | |
final | 24.8 | 24.3 | 24.3 | 24.5 | |
Upset stomach | |||||
recruitment | 12.3 | 13.3 | 11.0 | 7.6 | 0.92 (0.66–1.29) |
2nd year' | 11.6 | 10.1 | 9.1 | 10.9 | |
final | 9.4 | 8.3 | 10.6 | 8.2 | |
Shortness of breath | |||||
recruitment | 20.0 | 14.9 | 18.5 | 13.9 | 0.97 (0.74–1.27) |
2nd year | 12.2 | 13.8 | 9.8 | 11.3 | |
final | 12.9 | 10.1 | 10.0 | 12.1 | |
Sore throat | |||||
recruitment | 10.4 | 13.7 | 10.2 | 11.4 | 1.14 (0.85–1.54) |
2nd year | 11.6 | 11.7 | 11.1 | 7.8 | |
final | 12.7 | 10.4 | 10.3 | 10.1 | |
Constant cough | |||||
recruitment | 6.0 | 7.9 | 7.0 | 6.3 | 1.11 (0.79–1.56) |
2nd year | 6.4 | 7.2 | 8.1 | 6.2 | |
final | 9.7 | 8.6 | 7.3 | 5.6 | |
Water retention | |||||
recruitment | 14.6 | 16.3 | 16.6 | 15.5 | 1.09 (0.79–1.50) |
2nd year | 13.4 | 15.2 | 14.8 | 11.8 | |
final | 16.2 | 13.6 | 16.1 | 15.1 | |
Loss of appetite | |||||
recruitment | 3.7 | 3.4 | 3.0 | 3.8 | 0.91 (0.69–1.20) |
2nd year | 3.5 | 2.9 | 2.0 | 3.5 | |
final | 3.0 | 3.4 | 3.3 | 3.3 | |
Vaginal bleeding | |||||
recruitment | 3.5 | 2.3 | 4.2 | 2.8 | 19.65 (12.15–31.79) |
1st year | 10.3 | 2.7 | 9.5 | 1.2 | |
final | 5.9 | 0.7 | 4.9 | 0.7 |