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Table 2 Proportion of women reporting different symptoms in each arm of the EPHT Trial over time* and the effect of hormone therapy on symptom reporting

From: Symptom reporting and quality of life in the Estonian Postmenopausal Hormone Therapy Trial

Symptom Non- blind HT (%) Non- treatment (%) Blind HT (%) Placebo (%) OR (95% CI)
Hot flushes      
   recruitment 43.4 41.1 46.2 48.4 0.20 (0.14–0.28)
   2nd year 10.8 22.9 9.1 26.2  
   final 14.6 23.6 13.1 22.5  
Sweating      
   recruitment 50.0 43.5 46.2 47.2 0.56 (0.44–0.72)
   2nd year 23.9 32.4 22.9 32.8  
   final 26.4 31.8 24.0 31.4  
Trouble sleeping      
   recruitment 31.4 30.3 30.2 34.3 0.66 (0.52–0.84)
   2nd year 25.6 31.1 24.9 32.0  
   final 34.1 36.2 31.3 33.3  
Depression      
   recruitment 27.1 27.2 23.4 21.0 0.81 (0.60–1.08)
   2nd year 19.9 21.1 19.2 22.8  
   final 21.6 23.6 18.9 19.3  
Anxiety      
   recruitment 34.4 36.1 34.6 33.2 0.93 (0.73–1.19)
   2nd year 27.1 25.7 28.3 27.8  
   final 27.3 29.5 25.2 25.2  
Backache      
   recruitment 40.2 40.0 42.1 36.0 1.15 (0.96–1.38)
   2nd year 38.7 37.0 35.7 37.3  
   final 45.4 37.2 39.5 35.6  
Stiffness/aches in joints      
   recruitment 57.5 54.5 56.3 54.2 0.97 (0.82–1.15)
   2nd year 50.3 56.4 50.8 57.0  
   final 57.5 56.5 54.4 56.5  
Chronic fatigue      
   recruitment 55.5 53.9 51.7 49.0 1.11 (0.90–1.35)
   2nd year 52.8 51.6 47.5 49.4  
   final 55.3 49.5 47.7 49.3  
Headache      
   recruitment 39.1 33.3 35.1 38.8 1.08 (0.76–1.54)
   2nd year 34.1 30.1 33.3 32.4  
   final 35.7 30.9 35.3 33.3  
Dizzy spells      
   recruitment 26.6 23.3 21.1 24.7 0.97 (0.74–1.28)
   2nd year 18.7 22.3 21.2 19.6  
   final 19.4 23.0 19.5 16.7  
Diarrhoea or constipation      
   recruitment 26.4 26.6 21.2 21.7 0.99 (0.75–1.30)
   2nd year 24.8 20.2 18.6 19.9  
   final 24.8 24.3 24.3 24.5  
Upset stomach      
   recruitment 12.3 13.3 11.0 7.6 0.92 (0.66–1.29)
   2nd year' 11.6 10.1 9.1 10.9  
   final 9.4 8.3 10.6 8.2  
Shortness of breath      
   recruitment 20.0 14.9 18.5 13.9 0.97 (0.74–1.27)
   2nd year 12.2 13.8 9.8 11.3  
   final 12.9 10.1 10.0 12.1  
Sore throat      
   recruitment 10.4 13.7 10.2 11.4 1.14 (0.85–1.54)
   2nd year 11.6 11.7 11.1 7.8  
   final 12.7 10.4 10.3 10.1  
Constant cough      
   recruitment 6.0 7.9 7.0 6.3 1.11 (0.79–1.56)
   2nd year 6.4 7.2 8.1 6.2  
   final 9.7 8.6 7.3 5.6  
Water retention      
   recruitment 14.6 16.3 16.6 15.5 1.09 (0.79–1.50)
   2nd year 13.4 15.2 14.8 11.8  
   final 16.2 13.6 16.1 15.1  
Loss of appetite      
   recruitment 3.7 3.4 3.0 3.8 0.91 (0.69–1.20)
   2nd year 3.5 2.9 2.0 3.5  
   final 3.0 3.4 3.3 3.3  
Vaginal bleeding      
   recruitment 3.5 2.3 4.2 2.8 19.65 (12.15–31.79)
   1st year 10.3 2.7 9.5 1.2  
   final 5.9 0.7 4.9 0.7  
  1. * Among those whose data available
  2. HT – hormone therapy
  3. OR – combined odds ratio for treatment versus no-treatment arms
  4. CI – confidence interval