Breast cancer risk and genetic ancestry: a case–control study in Uruguay

BMC Women's Health

Table 4 Mitochondrial DNA haplogroups in breast cancer cases and controls from Uruguay

Haplogroup	Cases	Controls	p-value
African	9	16
L	9	16
Native American	55	65	0.40^a
A	11	19
B	21	16
C	16	21
D	7	9
European	99	83	0.26^a
H	48	27
HV	1	3
I	0	1
J	9	5
K	4	8
N	1	1
R	0	2
T	9	11
U1-5	8	8
U6	12	9
V	2	0
W	3	6
X	2	2
Total	163^d	164	0.20^b/0.12^c

^aP-value corresponding to the Pearson’s X² statistic obtained when examining differences in haplogroup distribution between cases and controls within each ancestry.
^bP-value obtained from testing the distribution of all mtDNA haplogroups in cases and controls using Pearson’s X² test.
^cP-value obtained from testing the Native American, African and European ancestral contributions in cases and controls using Pearson’s X² test.
^dAn individual carrying a G haplogroup, which is of Asian origin, was not included in the analysis.

ISSN: 1472-6874