TY - JOUR AU - Duan, Peng AU - Wang, Zhi-Ming AU - Liu, Jiang AU - Wang, Li-Na AU - Yang, Zhi AU - Tu, Ping PY - 2015 DA - 2015/04/13 TI - Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women JO - BMC Women's Health SP - 32 VL - 15 IS - 1 AB - Age at menarche (AAM) and age at natural menopause (AANM) have been shown intimately associated with woman’s health later in life. Previous studies have indicated that AAM and AANM are highly heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which is also found associated with post-menopausal and hormone-related diseases. The aim of this study was to evaluate associations between the polymorphisms in the TNFSF11, TNFRSF11A and TNFRSF11B genes in the RANKL/RANK/OPG pathway with AAM and AANM in Chinese women. SN - 1472-6874 UR - https://doi.org/10.1186/s12905-015-0192-3 DO - 10.1186/s12905-015-0192-3 ID - Duan2015 ER -