Fig. 2
The location, function and structure of ERCC1. a The location of RECC1. ERCC1, excision repair cross complementation group 1. b The function of ERCC1. XPC binds to DNA damage site (red circle), XPA, XPG, RPA and TFIIH attach to the distorted DNA and then nucleases make the incisions on the damaged strand. ERCC1–XPF complex cuts 5′ of the lesion, whereas XPG cuts 3′. The excised DNA is replaced in a DNA-repair synthesis reaction that is catalyzed by DNA polymerase. XPA: Xeroderma pigmentosum complementation group A; XPC: Xeroderma pigmentosum complementation group C; XPF: Xeroderma pigmentosum complementation group F; XPG: Xeroderma pigmentosum complementation group G; RPA: Replication protein A; TFIIH: Transcription factor II Human; c The structure of ERCC1. ERCC1 contains a central domain (from 96 amino acid residue to 214 amino acid residue) and an HhH2 domain (from 240 amino acid residue to 297 amino acid residue). The HhH2 domain is linked to XPF, whereas the central domain combines with DNA. HhH2, helix-hairpin-helix domain