Table 2 Genotype and Allele Distribution of ERCC1 Polymorphisms in ovarian cancer Resistant and Responders
SNP | Study | Resistant | Responder | Resistant | Responder | HWE | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C/C | C/T | T/T | C | T | C/C | C/T | T/T | C | T | Number (%) | Number (%) | Chi | p | ||
ERCC1 C19007T | Sokbom K. et al. [18] | 15 | 5 | 0 | 35 | 5 | 20 | 16 | 4 | 56 | 24 | 20 (50) | 40 (50) | 0.09 | 0.76 |
Steffensen K.D. et al. [20] | 16 | 72 | 67 | 104 | 206 | 15 | 71 | 58 | 101 | 187 | 155 (52) | 144 (48) | 0.98 | 0.32 | |
Smith S. et al. [16] | 11 | 22 | 15 | 44 | 52 | 23 | 60 | 45 | 106 | 150 | 48 (27) | 128 (73) | 0.15 | 0.71 | |
Qi B. et al. [11] | 38 | 26 | 9 | 102 | 44 | 78 | 67 | 2 | 223 | 71 | 73 (33) | 147 (67) | 8.76 | 0.003 | |
Bösmüller H. et al. [19] | 6 | 5 | 3 | 17 | 11 | 7 | 9 | 11 | 23 | 31 | 14 (34) | 27 (66) | 2.74 | 0.1 | |
Steffensen K.D. et al. [17] | 3 | 7 | 2 | 13 | 11 | 12 | 34 | 42 | 58 | 118 | 12 (12) | 88 (88) | 1.39 | 0.24 | |
Moxley K.M. et al. [10] | 10 | 13 | 9 | 33 | 31 | 14 | 8 | 10 | 36 | 28 | 32 (50) | 32 (50) | 8.04 | 0.005 | |
Yang S. [21] | 28 | 31 | 12 | 87 | 55 | 70 | 67 | 1 | 207 | 69 | 71 (34) | 138 (66) | 11.98 | 0.0005 | |