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Table 3 Meta-analysis by Genetic Models for C19007T Polymorphisms

From: Association between the ERCC1 polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer: a meta-analysis

SNP

Genetic model

Participants (%)

OR (95% CI)

Z

P value

I2%

Phet

Effect model

Begg’s test p > │z│

Egger’s test p > │t│

Harbord test p > │t│

ERCC1 C19007T

CC vs. CT + TT

1169 (50)

1.0 (0.75, 1.33)

0

0.99

26.6

0.22

Fixed

0.08

0.06

0.07

TT vs. CT + CC

1169 (50)

1.16 (0.53, 2.55)

0.38

0.7

72.5

0.001

Random

0.81

0.83

0.91

CC vs. CT

879 (39)

1.10 (0.81, 1.49)

0.59

0.56

0.0

0.66

Fixed

0.62

0.72

0.75

CC vs. TT

656 (28)

0.85 (0.33, 2.22)

0.33

0.74

72.4

0.001

Random

0.81

0.86

0.56

C vs. T

2338 (100)

1.07 (0.75, 1.52)

0.38

0.7

66.9

0.004

Random

0.03

0.06

0.07

  1. ERCC1 excision repair cross complementation group 1