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Table 3 Univariate and multivariate analyses on factors associated with hypertension at study entry, by stepwise logistic regression

From: Profiles of lipids, blood pressure and weight changes among premenopausal Chinese breast cancer patients after adjuvant chemotherapy

 

Univariate analysis

Multivariate analysis

OR

95% CI for OR

p

OR

95% CI for OR

p

Age at diagnosis

1.243

0.869–1.779

0.2343

   

  ≤ 35

1

-

   

 36–40

1.000

0.429–2.331

1.0000

  

 41–45

1.417

0.658–3.050

0.3727

  

>/= 1 children before breast cancer diagnosis

1.291

0.715–2.332

0.3695

  

1st degree relative with breast cancer

0.926

0.316–2.715

0.8885

  

ER positive

0.517

0.298–0.895

0.0186

0.552

0.311–0.980

0.0423

PR positive

0.712

0.419–1.213

0.2115

   

HER2 over-expression

1.187

0.610–2.309

0.6134

  

Received adjuvant radiotherapy

0.866

0.508–1.477

0.5984

  

Received adjuvant taxane-containing chemotherapy

0.887

0.501–1.568

0.6790

  

Duration of adjuvant chemotherapy >64 days

0.828

0.483–1.420

0.4928

  

Received corticosteroid premedication during chemotherapy

1.046

0.410–2.667

0.9251

  

Received adjuvant tamoxifen therapy

0.557

0.313–0.990

0.0462

  

Received adjuvant trastuzumab

1.352

0.316–5.789

0.6846

  

Use of traditional Chinese medicine since diagnosis

0.947

0.542–1.655

0.8486

  

Education

0.789

0.507–1.228

0.2936

  

 Primary school

1

-

-

  

 Secondary school

0.907

0.461–1.787

0.7784

  

 Tertiary school + Higher qualification

0.609

0.246–1.509

0.2840

  

Employment- Working

0.815

0.485–1.369

0.4397

  

Family income </= HK$ 25,000

0.753

0.441–1.287

0.3000

  

Ever Smoker

0.271

0.033–2.198

0.2214

  

Ever excessive alcohol intake (>2 units/day)

-

-

0.9877

  

Chemotherapy-related amenorrhea

0.778

0.329–1.838

0.5665

  

Post/peri- menopausal at study entry

0.930

0.559–1.548

0.7808

  

Weight gain >2% at study entry

1.095

0.644–1.864

0.7371

  

Total Cholesterol >/= 5.2 mmol/L

1.475

0.865–2.516

0.1534

  

LDL Cholesterol >/= 2.6 mmol/L

1.762

1.027–3.021

0.0396

  

HDL Cholesterol </= 1.0 mmol/L

1.842

0.700–4.850

0.2160

  

Triglyceride >/=1.7 mmol/L

1.568

0.867–2.836

0.1364

  

Overweight/obese at study entry

2.751

1.608–4.707

0.0002

2.723

1.568–4.728

0.0004

Age at study entry

1.173

0.852–1.614

0.3273

   

  ≤ 40

1

-

   

 41–45

1.929

0.738–5.037

0.1799

  

 46–50

1.774

0.720–4.371

0.2126

  

  > 50

2.057

0.623–6.794

0.2367

  
  1. Hypertension defined as systolic blood pressure >/= 140 mmHg, or diastolic blood pressure >/=90 mmHg