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Table 4 Factors identified to be associated with dyslipidaemia based on multivariate analysis, by stepwise logistic regression

From: Profiles of lipids, blood pressure and weight changes among premenopausal Chinese breast cancer patients after adjuvant chemotherapy

  Univariate analysis Multivariate analysis
OR 95% CI for OR p OR 95% CI for OR P
Total cholesterol: high (n = 93) vs normal (n = 178)
 Overweight/obese at study entry 1.760 1.032–3.003 0.0379 1.764 1.013–3.073 0.0451
 Age at study entry 2.101 1.467–3.010 <0.0001 2.093 1.461–2.997 <0.0001
   ≤ 40 1 -     
  41–45 1.490 0.494–4.489 0.4789   
  46–50 3.838 1.397–10.548 0.0091   
   > 50 7.020 1.989–24.772 0.0025   
LDL cholesterol: high (n = 152) vs normal (n = 115)
 Received corticosteroid premedication during chemotherapy 7.576 1.724–33.33 0.0074 5.747 1.264–26.32 0.0236
 Received adjuvant tamoxifen 0.388 0.209–0.720 0.0027 0.342 0.179–0.656 0.0012
 Overweight/obese at study entry 2.468 1.407–4.330 0.0016 2.560 1.410–4.649 0.0020
 Age at study entry 1.626 1.192–2.217 0.0021 1.625 1.165–2.266 0.0042
   ≤ 40 1 -     
  41–45 0.963 0.420–2.212 0.9298   
  46–50 1.763 0.813–3.823 0.1510   
   > 50 5.383 1.493–19.407 0.0101   
HDL cholesterol: low (n = 18) vs. normal (n = 251)
 Ever smoker 4.357 0.836–22.707 0.0806 7.772 1.102–54.827 0.0397
 Post/peri- menopausal at study entry 3.881 1.243–12.114 0.0196 3.629 1.144–11.509 0.0286
 Overweight/obese at study entry 8.193 1.845–36.372 0.0057 7.786 1.742–34.795 0.0072
Triglyceride: high (n = 62) vs. normal (n = 209)
 Adjuvant taxane-containing chemotherapy 2.040 1.124–3.704 0.0192 2.552 1.317–4.944 0.0055
 Weight gain >2% 2.258 1.171–4.355 0.0150 2.213 1.084–4.517 0.0292
 Overweight/obese at study entry 2.306 1.282–4.149 0.0053 2.775 1.446–5.325 0.0021
 Age at study entry 1.641 1.118–2.410 0.0114 1.969 1.285–3.017 0.0019
   ≤ 40 1 -     
  41–45 1.355 0.401–4.573 0.6246   
  46–50 2.558 0.842–7.773 0.0978   
   > 50 3.733 0.964–14.461 0.0566   
  1. Definitions of abnormal lipids: total cholesterol >/=5.2 mmol/L; LDL cholesterol >/= 2.6 mmol/L; HDL cholesterol </= 1.0 mmol/L; triglyceride >1.7 mmol/L