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Table 4 Factors identified to be associated with dyslipidaemia based on multivariate analysis, by stepwise logistic regression

From: Profiles of lipids, blood pressure and weight changes among premenopausal Chinese breast cancer patients after adjuvant chemotherapy

 

Univariate analysis

Multivariate analysis

OR

95% CI for OR

p

OR

95% CI for OR

P

Total cholesterol: high (n = 93) vs normal (n = 178)

 Overweight/obese at study entry

1.760

1.032–3.003

0.0379

1.764

1.013–3.073

0.0451

 Age at study entry

2.101

1.467–3.010

<0.0001

2.093

1.461–2.997

<0.0001

   ≤ 40

1

-

    

  41–45

1.490

0.494–4.489

0.4789

  

  46–50

3.838

1.397–10.548

0.0091

  

   > 50

7.020

1.989–24.772

0.0025

  

LDL cholesterol: high (n = 152) vs normal (n = 115)

 Received corticosteroid premedication during chemotherapy

7.576

1.724–33.33

0.0074

5.747

1.264–26.32

0.0236

 Received adjuvant tamoxifen

0.388

0.209–0.720

0.0027

0.342

0.179–0.656

0.0012

 Overweight/obese at study entry

2.468

1.407–4.330

0.0016

2.560

1.410–4.649

0.0020

 Age at study entry

1.626

1.192–2.217

0.0021

1.625

1.165–2.266

0.0042

   ≤ 40

1

-

    

  41–45

0.963

0.420–2.212

0.9298

  

  46–50

1.763

0.813–3.823

0.1510

  

   > 50

5.383

1.493–19.407

0.0101

  

HDL cholesterol: low (n = 18) vs. normal (n = 251)

 Ever smoker

4.357

0.836–22.707

0.0806

7.772

1.102–54.827

0.0397

 Post/peri- menopausal at study entry

3.881

1.243–12.114

0.0196

3.629

1.144–11.509

0.0286

 Overweight/obese at study entry

8.193

1.845–36.372

0.0057

7.786

1.742–34.795

0.0072

Triglyceride: high (n = 62) vs. normal (n = 209)

 Adjuvant taxane-containing chemotherapy

2.040

1.124–3.704

0.0192

2.552

1.317–4.944

0.0055

 Weight gain >2%

2.258

1.171–4.355

0.0150

2.213

1.084–4.517

0.0292

 Overweight/obese at study entry

2.306

1.282–4.149

0.0053

2.775

1.446–5.325

0.0021

 Age at study entry

1.641

1.118–2.410

0.0114

1.969

1.285–3.017

0.0019

   ≤ 40

1

-

    

  41–45

1.355

0.401–4.573

0.6246

  

  46–50

2.558

0.842–7.773

0.0978

  

   > 50

3.733

0.964–14.461

0.0566

  
  1. Definitions of abnormal lipids: total cholesterol >/=5.2 mmol/L; LDL cholesterol >/= 2.6 mmol/L; HDL cholesterol </= 1.0 mmol/L; triglyceride >1.7 mmol/L