Skip to main content

Table 3 Summary of studies looked at endometrial αVβ3 integrin in luteal phase of infertile women

From: AlphaVBeta3 Integrin expression within uterine endometrium in unexplained infertility: a prospective cohort study

Authors Population Main outcome measures Control Results
Lessey et al., 1995 [25] 87 Women with unexplained infertility β3 integrin expression on cycle day 20–24 32 parous women Reduced expression in infertile women with 26% and 39% had out-of-phase and in-phase defects, respectively
Creus et al., 2002 [18] 36 infertile patients Endometrial αVβ3 integrin expression and pinopod formation on postovulatory day +7 to +8 and 4 days later 12 normal healthy women No difference was found between fertile controls and infertile patients irrespective of endometria being in-phase or out-of-phase
Tei et al., 2003 [12] 57 infertile women, 22 of which with unexplained infertility Endometrial αVβ3 expression in mid-secretory endometrium 10 fertile women Endometrial αVβ3 expression was lower in women with unexplained infertility compared to fertile women and women with explained infertility
Ceydeli et al., 2005 [22] 33 infertile women Mid-luteal endometrial glandular, luminal and stromal αVβ3 integrin expression during implantation window 33 fertile women Average αVβ3 integrin expression was similar in different sites in both infertile and fertile women
Boroujerdnia& Nikbakht, 2008 [16] 30 women with unexplained infertility Endometrial αVβ3 expression during implantation window 30 endometrial biopsies from hysterectomies with non-endometrial pathology Endometrial glandular expression of β3 integrin was reduced significantly in infertile endometrium while no difference in stromal or blood vessel expression
Casals et al., 2008 [20] 107 infertile women Endometrial αVβ3 integrin and osteopontin co-expression on post-ovulatory day +6 to +8, and 4 days later 12 normal healthy women No difference regarding αVβ3 integrin and osteopontin co-expression was found between fertile controls and infertile patients irrespective of endometria being in-phase or out-of-phase
Casals et al., 2012 [17] 20 infertile patients with stage I or II endometriosis as the only detectable cause of infertility and 20 infertile patients with unexplained infertility Endometrial expression and co-expression of osteopontin and αvβ3 integrin in postovulatory day +7 to +8 and 4 days later 20 infertile women undergoing tubal sterilization Similar αvβ3 integrin and osteopontin expression between infertile patients with endometriosis and the two control groups