Table 3 Summary of studies looked at endometrial αVβ3 integrin in luteal phase of infertile women
Authors | Population | Main outcome measures | Control | Results |
|---|---|---|---|---|
Lessey et al., 1995 [25] | 87 Women with unexplained infertility | β3 integrin expression on cycle day 20–24 | 32 parous women | Reduced expression in infertile women with 26% and 39% had out-of-phase and in-phase defects, respectively |
Creus et al., 2002 [18] | 36 infertile patients | Endometrial αVβ3 integrin expression and pinopod formation on postovulatory day +7 to +8 and 4 days later | 12 normal healthy women | No difference was found between fertile controls and infertile patients irrespective of endometria being in-phase or out-of-phase |
Tei et al., 2003 [12] | 57 infertile women, 22 of which with unexplained infertility | Endometrial αVβ3 expression in mid-secretory endometrium | 10 fertile women | Endometrial αVβ3 expression was lower in women with unexplained infertility compared to fertile women and women with explained infertility |
Ceydeli et al., 2005 [22] | 33 infertile women | Mid-luteal endometrial glandular, luminal and stromal αVβ3 integrin expression during implantation window | 33 fertile women | Average αVβ3 integrin expression was similar in different sites in both infertile and fertile women |
Boroujerdnia& Nikbakht, 2008 [16] | 30 women with unexplained infertility | Endometrial αVβ3 expression during implantation window | 30 endometrial biopsies from hysterectomies with non-endometrial pathology | Endometrial glandular expression of β3 integrin was reduced significantly in infertile endometrium while no difference in stromal or blood vessel expression |
Casals et al., 2008 [20] | 107 infertile women | Endometrial αVβ3 integrin and osteopontin co-expression on post-ovulatory day +6 to +8, and 4 days later | 12 normal healthy women | No difference regarding αVβ3 integrin and osteopontin co-expression was found between fertile controls and infertile patients irrespective of endometria being in-phase or out-of-phase |
Casals et al., 2012 [17] | 20 infertile patients with stage I or II endometriosis as the only detectable cause of infertility and 20 infertile patients with unexplained infertility | Endometrial expression and co-expression of osteopontin and αvβ3 integrin in postovulatory day +7 to +8 and 4 days later | 20 infertile women undergoing tubal sterilization | Similar αvβ3 integrin and osteopontin expression between infertile patients with endometriosis and the two control groups |