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Table 2 Risk Factors in the Study Population, p-values from Chi-square test for Comparison between Cases and Controls

From: Oral contraceptive and breast cancer: do benefits outweigh the risks? A case – control study from Jordan

Factor

Cases (n = 224)

N (%)

Controls (n = 225)

N (%)

p-value1

Age in years (N = 449)

 18–35

31 (13.84)

31 (13.78)

0.988

 36–45

89 (39.73)

91 (40.44)

 

 46–65

104 (46.43)

103 (45.78)

 

Breastfeeding (N = 450)

 Yes

144 (64)

154 (68.44)

0.522

 No

25 (11.11)

19 (8.44)

 

 N/A*

56 (24.89)

52 (23.11)

 

Duration of breastfeeding in years (N = 449)

  ≤ 1

50 (22.32)

61 (27.11)

0.610

  > 1

94 (41.96)

93 (41.33)

 

 No

24 (10.71)

19 (8.44)

 

 N/A*

56 (25)

52 (23.11)

 

Pregnancy (N = 450)

 Yes

115 (51.11)

173 (76.89)

0.000

 No

110 (48.890

52 (23.11)

 

Miscarriage (N = 450)

 Yes

92 (40.89)

84 (37.33)

0.249

 No

133 (59.11)

141 (62.67)

 

Menopausal Status (N = 450)

 Premenopausal

101 (44.89)

74 (32.89)

0.006

 Postmenopausal

124 (55.11)

151 (67.11)

 

Regularity of Period (N = 449)

 Yes

190 (84.82)

203 (90.22)

0.056

 No

34 (15.18)

22 (9.78)

 

Personal history of cancer (ovarian, rectal, etc.) (N = 449)

 Yes

27 (12.05)

0 (0)

0.000

 No

197 (87.95)

225 (100)

 

First or second – degree relative have cancer (N = 449)

 Yes

109 (48.66)

34 (15.11)

0.000

 No

115 (51.34)

191 (84.89)

 

Smoking Status (N = 448)

 Past Smoker

25 (11.21)

1 (0.44)

0.000

 Current Smoker

11 (4.93)

25 (11.11)

 

 Never Smoked

187 (83.86)

199 (88.44)

 

Hormonal Therapy for Menstrual Irregularities (N = 447)

 Yes

24 (10.81)

13 (5.78)

0.060

 No

198 (89.19)

212 (94.22)

 

Postmenopausal Hormonal Therapy (i = 448)

 Yes

8 (3.59)

0 (0)

0.004

 No

215 (96.41)

225 (100)

 

Regular Use of Oral Contraceptives (N = 446)

 Yes

87 (39.01)

48 (21.52)

0.000

 No

136 (60.99)

175 (78.48)

 

Oral Contraceptives Type (N = 81)

 COC*

31 (49.21)

10 (55.56)

0.063

 POC*

32 (50.79)

8 (44.44)

 
  1. *N/A Not Applicable
  2. *POC Progestin-Only Contraceptives
  3. *COCs Combined Oral Contraceptives
  4. 1Chi-square test