Skip to main content

Table 2 Summary of findings table for presenting risks and quality of evidence about recruited studies

From: Secnidazole for treatment of bacterial vaginosis: a systematic review

One gr Secnidazole compared to placebo for bacterial vaginosis
Bibliography: secnidazole for bacterial vaginosis. Cochrane Database of Systematic Reviews [Year], Issue [Issue].
Certainty assessment Summary of findings
№ of participants (studies) Follow-up Risk of bias Inconsistency Indirectness Imprecision Publication bias Overall certainty of evidence Study event rates (%) Relative effect (95% CI) Anticipated absolute effects
With placebo With 1 g Secnidazole Risk with placebo Risk difference with 1 g Secnidazole
clinical cure rate
126 (1 RCT) not serious not serious not serious not serious none HIGH 11/62 (17.7%) 33/64 (51.6%) RR 2.92* (1.64 to 5.19) 177 per 1000 341 more per 1000 (from 114 more to 743 more)
clinical cure rate - Clinical cure of pts. with 3 or less episodes of BV in the last year
87 (1 RCT) not serious not serious not serious not serious none HIGH 10/43 (23.3%) 26/44 (59.1%) RR 2.54* (1.40 to 4.61) 233 per 1000 358 more per 1000 (from 93 more to 840 more)
clinical cure rate - Clinical cure of pts. with 4 or more episodes of BV in the last year
39 (1 RCT) not serious not serious not serious very serious a none LOW 1/19 (5.3%) 7/20 (35.0%) RR 6.65 (0.90 to 49.09) 53 per 1000 297 more per 1000 (from 5 fewer to 1000 more)
Microbiologic cure rate
126 (1 RCT) not serious not serious not serious not serious none HIGH 4/62 (6.5%) 15/64 (23.4%) RR 3.35* (1.26 to 8.95) 65 per 1000 152 more per 1000 (from 17 more to 513 more)
Microbiologic cure rate - Microbiologic cure of pts. with 3 or less episodes of BV in the last year
87 (1 RCT) not serious not serious not serious not serious none HIGH 4/43 (9.3%) 13/44 (29.5%) RR 3.18* (1.12 to 8.98) 93 per 1000 203 more per 1000 (from 11 more to 742 more)
Therapeutic cure rate
126 (1 RCT) not serious not serious not serious not serious none HIGH 4/62 (6.5%) 14/64 (21.9%) RR 3.14* (1.17 to 8.42) 65 per 1000 138 more per 1000 (from 11 more to 479 more)
Therapeutic cure rate - Therapeutic cure of pts. with 3 or less episodes of BV in the last year
87 (1 RCT) not serious not serious not serious not serious none HIGH 4/43 (9.3%) 13/44 (29.5%) RR 3.18* (1.12 to 8.98) 93 per 1000 203 more per 1000 (from 11 more to 742 more)
Therapeutic cure rate - Therapeutic cure of pts. with 4 or more episodes of BV in the last year
  1. * significant (p <0.05)
  2. CI Confidence interval, RR Risk ratio
  3. Explanations
  4. aA very wide confidence interval
  5. bLarge confidence interval
  6. Bold data are significant