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Table 1 PICOS framework

From: Comparative efficacy of statins, metformin, spironolactone and combined oral contraceptives in reducing testosterone levels in women with polycystic ovary syndrome: a network meta-analysis of randomized clinical trials

PopulationWomen with PCOS
InterventionStatins
ComparatorCombined oral contraceptives (COC), metformin, placebo, lifestyle modification, or spironolactone
OutcomeReduction in the blood level of testosterone
Study designPublished or unpublished randomized controlled trials