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Table 1 PICOS framework

From: Comparative efficacy of statins, metformin, spironolactone and combined oral contraceptives in reducing testosterone levels in women with polycystic ovary syndrome: a network meta-analysis of randomized clinical trials

Population

Women with PCOS

Intervention

Statins

Comparator

Combined oral contraceptives (COC), metformin, placebo, lifestyle modification, or spironolactone

Outcome

Reduction in the blood level of testosterone

Study design

Published or unpublished randomized controlled trials