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Table 3 Studies that were included in the network meta-analysis

From: Comparative efficacy of statins, metformin, spironolactone and combined oral contraceptives in reducing testosterone levels in women with polycystic ovary syndrome: a network meta-analysis of randomized clinical trials

Author

Year

Country

Follow-up period

Design for the study

n

Age (yr.)

BMI (Kg/m2)

Intervention

Control

Ganie et al. [3]

2004

India

6 months

Randomized open-labelled clinical trial

69

17.6–28.5

20.9–32.1

Spironolactone (n = 34)

Metformin(n = 35)

Hoeger et al. [4]

2008

USA

24 weeks

Randomized clinical trial

43

13.7–17.7

27.8–46.0

Metformin (n = 10),

COC (n = 11), or

lifestyle modification (n = 11)

Placebo (n = 11)

Sathyapalan et al. [5]

2009

UK

12 weeks

Randomized double-blind clinical trial

37

26.3–29.1

31.8–35.4

Atorvastatin (n = 19)

Placebo (n = 18)

Kazerooni et al. [1]

2010

Iran

12 weeks

Randomized double-blind clinical trial

84

19.1–30.7

27.3–30.3

Metformin + Simvastatin (n = 42)

Metformin + Placebo (n = 42)

Romualdi et al. [6].

2010

Italy

6 months

Randomized double-blind clinical trial

28

20.3–29.8

18.4–26.2

Metformin (n = 15)

Placebo (n = 13)

Teede et al. [7]

2010

Australia

6 months

Randomized clinical trial

66

26.8–40.2

34.3–37.8

Metformin (n = 36)

COCs (n = 30)

Raja-Khan et al. [8]

2011

USA

6 weeks

Randomized double-blind clinical trial

20

23.6–38.1

25.6–51.9

Atorvastatin (n = 9)

Placebo (n = 11)

Banaszewska et al. [2]

2011

Poland

6 months

Randomized open-labelled clinical trial

97

24.7–26.9

22.9–25.6

Simvastatin + Metformin (n = 36)

Simvastatin (n = 28) or

Metformin (n = 33)

Ganie et al. [9]

2013

India

6 months

Randomized open-labelled clinical trial

169

17.2–28.8

20.0–30.1

Spironolactone + Metformin (n = 62)

Spironolactone (n = 51) or Metformin (n = 56)