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Table 4 Network meta-analysis and pairwise meta-analysis of all interventions (Random Effect)

From: Comparative efficacy of statins, metformin, spironolactone and combined oral contraceptives in reducing testosterone levels in women with polycystic ovary syndrome: a network meta-analysis of randomized clinical trials

Atorvastatin       −3.04 [− 3.56; − 2.53]
−2.78 [− 3.60; − 1.97]COC    − 0.18 [− 0.70; 0.34]− 0.31 [− 1.08; 0.46]− 0.35 [− 1.16; 0.46]
−2.83 [− 3.80; − 1.87]− 0.05 [− 0.87; 0.78]MetSpiro − 0.09 [− 0.80; 0.62].− 0.11 [− 0.80; 0.58]..
−2.88 [− 3.85; − 1.92]− 0.10 [− 0.92; 0.72]−0.05 [− 0.96; 0.86]Simvastatin.− 0.06 [− 0.74; 0.62]−0.07 [− 0.75; 0.61]..
−2.90 [−3.77; − 2.02]−0.11 [− 0.83; 0.61]−0.06 [− 0.72; 0.59]−0.01 [− 0.83; 0.80]Spironolactone.− 0.07 [− 0.58; 0.43]..
−2.93 [− 3.79; − 2.06]−0.14 [− 0.85; 0.56]−0.09 [− 0.90; 0.72]−0.04 [− 0.68; 0.60]−0.03 [− 0.73; 0.67]SimvMet−0.04 [− 0.53; 0.44]..
−2.97 [−3.69; − 2.25]−0.19 [− 0.70; 0.33]−0.14 [− 0.78; 0.51]−0.09 [− 0.73; 0.55]−0.07 [− 0.58; 0.43]−0.04 [− 0.53; 0.44]Metformin−0.02 [− 0.70; 0.67]−0.05 [− 0.56; 0.47]
−3.02 [− 3.87; − 2.18]−0.24 [− 0.93; 0.45]−0.19 [− 1.09; 0.71]−0.14 [− 1.03; 0.75]−0.13 [− 0.93; 0.67]−0.10 [− 0.89; 0.69]−0.05 [− 0.68; 0.57]Lifestyle−0.03 [− 0.76; 0.70]
− 3.04 [− 3.56; − 2.53]−0.26 [− 0.89; 0.38]−0.21 [− 1.03; 0.61]−0.16 [− 0.97; 0.65]−0.15 [− 0.86; 0.56]−0.12 [− 0.81; 0.58]−0.07 [− 0.57; 0.43]−0.02 [− 0.68; 0.65]Placebo
  1. Treatments were ranked from best to least along the leading diagonal from the random-effect analysis. Above the leading diagonal are estimates from pairwise meta-analyses and below are estimates from the network meta-analyses. Data presented are mean difference (MD) with 95% confidence interval (95%CI) or 95% credible interval (95%CrI) for the pairwise meta-analysis or network meta-analysis, respectively. MD below 0 indicate higher efficacy in reducing testosterone level. Bold values indicate comparisons that are statistically significant
  2. Abbreviations: COC combined oral contraceptive, MetSpiro Spironolactone plus Metformin, SimvMet Metformin plus Simvastatin