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Table 3 Association between mitochondrial DNA copy number and cervical cancer

From: Mitochondrial DNA copy number in cervical exfoliated cells and risk of cervical cancer among HPV-positive women

Variables Quartiles of mtCN a Ptrend Pinteractionc
1st quartile 2nd quartile 3rd quartile 4th quartile
Reference OR (95% CI) b OR (95% CI) b OR (95% CI) b
Age (years)
 < 50 1.00 0.87(0.49–1.55) 1.25(0.74–2.10) 1.44(0.87–2.40) 0.08 0.40
 ≥ 50 1.00 1.14(0.61–2.16) 2.10(1.10–4.02) 2.32(1.24–4.35) 0.002
HPV16
 Negative 1.00 1.10(0.67–1.89) 2.09(1.26–3.46) 2.03(1.23–3.33) 0.001 0.21
 Positive 1.00 1.00(0.55–2.10) 0.79(0.40–1.57) 1.56(0.77–3.16) 0.34
HPV18
 Negative 1.00 1.08(0.74–1.68) 1.57(1.02–2.41) 1.67(1.10–2.53) 0.01 0.26
 Positive 1.00 0.56(0.26–2.47) 1.30(0.38–4.50) 2.97(0.77–11.38) 0.07
HPV52
 Negative 1.00 0.97(0.71–1.55) 1.46(0.93–2.3) 1.88(1.21–2.92) 0.002 0.77
 Positive 1.00 1.31(0.44–3.43) 1.85(0.71–4.8) 1.67(0.65–4.28) 0.24
HPV58
 Negative 1.00 1.04(0.73–1.62) 1.54(1.00–2.37) 1.71(1.12–2.61) 0.003 0.65
 Positive 1.00 0.58(0.27–2.44) 1.65(0.50–5.49) 2.15(0.69–6.67) 0.08
Others
 Negative 1.00 1.22(0.66–2.12) 1.14(0.68–1.90) 1.80(1.10–2.96) 0.03 0.25
 Positive 1.00 0.81(0.57–1.63) 2.40(1.22–4.71) 1.94(0.99–3.81) 0.003
Multiple infection
 Negative 1.00 1.10(0.74–1.71) 1.57(1.03–2.39) 1.82(1.21–2.74) 0.001 0.25
 Positive 1.00 0.26(0.16–1.82) 1.07(0.18–6.37) 1.11(0.19–6.56) 0.42
  1. Bold values indicate P < 0.05
  2. Abbreviation: HPV human papillomavirus, mtCN mitochondrial DNA copy number, OR odds ratio, CI confidential interval
  3. aQuartiles of mtDNA copy number were assigned based on the distribution among controls
  4. bDerived from logistic regression with adjustment for age, HPV 16, 18, 52, 58 and the other high-risk HPV types where appropriate
  5. cInteraction analysis was conducted by adding a multiplicative interaction term in unconditional logistic regression models