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Table 2 Characteristics of participants at the three assessment clinics (N = 2411)

From: Changes in six domains of cognitive function with reproductive and chronological ageing and sex hormones: a longitudinal study in 2411 UK mid-life women

 

Clinic 1

Clinic 2

Clinic 3

N = 1981

N = 2050

N = 1981

Age, mean (SD)

50.9 (4.4)

52.2 (4.4)

53.3 (4.4)

Years since final menstrual period, mean (SD)

1.90 (3.4)

2.54 (3.8)

3.19 (4.3)

Menopausal stage

 Pre-menopause, N (%)

749 (38%)

544 (27%)

394 (20%)

 Peri-menopause, N (%)

532 (27%)

532 (26%)

479 (24%)

 Post-menopause, N (%)

659 (33%)

807 (39%)

925 (47%)

 Unable to determine, N (%)

41 (2%)

167 (8%)

183 (9%)

Cognitive function score

 Immediate verbal episodic memory, mean (SD), sample range 3–25

15.6 (3.6)

16.0 (3.3)

16.6 (3.3)

 Delayed verbal episodic memory, mean (SD), sample range 0–25

14.4 (3.8)

15.0 (3.6)

15.9 (3.5)

 Working memory, mean (SD), sample range 2–14

7.1 (2.4)

7.2 (2.3)

7.4 (2.3)

 Processing speed, mean (SD), sample range 10–133

80.7 (13.8)

82.8 (13.6)

83.7 (14.0)

 Verbal intelligence, mean (SD), sample range 0–60

44.1 (7.7)

44.2 (7.3)

44.2 (7.4)

 Verbal fluency, mean (SD), sample range 0–98

43.2 (12.0)

45.1 (12.5)

45.8 (12.6)

Education

 CSE / Vocational / O-level, N (%)

925 (47%)

977 (48%)

930 (47%)

 A-level, N (%)

597 (30%)

618 (30%)

599 (30%)

 Degree, N (%)

459 (23%)

455 (22%)

452 (23%)

Age at first pregnancy, mean (SD)

26.7 (4.7)

26.6 (4.8)

26.6 (4.7)

Reproductive hormones

 AMH (ng/ml), median (IQR)

0.01 (0.01–0.17)

0.01 (0.01–0.08)

0.01 (0.01–0.03)

 FSH (mIU/ml), median (IQR)

35.9 (7.4–74.2)

58.0 (11.7–87.9)

63.8 (18.7–88.9)

 LH (mIU/ml), median (IQR)

24.4 (7.3–40.0)

31.5 (10.6–44.0)

31.8 (15.4–43.2)

  1. AMH anti-Müllerian hormone, FSH follicle-stimulating hormone, IQR interquartile range, LH luteinizing hormone, SD standard deviation