Parameter | LNG | ENG | CuID | SIUD | P value1 | P value2 |
---|---|---|---|---|---|---|
SHBG (nmol/L) |  |  |  | 0.403 |  < 0.001 | |
 Stage 1 | 97.5 ± 79* (68.8) | 112.5 ± 73.7†(84.4) | 71.4 ± 51.2 (54.9) | 100.4 ± 79.2£ (77) |  |  |
 Stage 2 | 51.7 ± 17.1* (52.6) | 61.8 ± 18†(63.5) | 46.1 ± 13.4 (47.3) | 38.2 ± 16.1£ (32.7) |  |  |
Total testosterone (mg/dL) | Â | Â | 0.301 | 0.141 | ||
 Stage 1 | 31.3 ± 21.2 (24.4) | 26 ± 15.8 (21.2) | 27.4 ± 17.1 (22.1) | 25.3 ± 9.6 (24) |  |  |
 Stage 2 | 33.5 ± 8.7 (32) | 26.3 ± 7 (27.3) | 32.3 ± 8.8 (31.6) | 32.7 ± 8.8 (34.8) |  |  |
Free testosterone (mg/dL) | Â | Â | Â | 0.519 | 0.941 | |
 Stage 1 | 0.4 ± 0.5 (0.2) | 0.3 ± 0.3 (0.2) | 1 ± 2.5 (0.3) | 1.1 ± 3.9 (0.2) |  |  |
 Stage 2 | 0.3 ± 0.3 (0.3) | 0.3 ± 0.1 (0.3) | 1.8 ± 5.8 (0.3) | 0.4 ± 0.2 (0.3) |  |  |
TSH (mU/L) | Â | Â | Â | 0.833 | 0.327 | |
 Stage 1 | 2.1 ± 1 (1.8) | 2 ± 1 (1.6) | 2.1 ± 1.7 (1.5) | 2.5 ± 1.9 (2.1) |  |  |
 Stage 2 | 2.1 ± 0.7 (2.2) | 2.2 ± 0.8 (2.1) | 1.9 ± 1 (1.6) | 1.7 ± 0.7 (1.7) |  |  |
Free T4 (ng/dL) | Â | Â | Â | 0.577 | 0.249 | |
 Stage 1 | 0.9 ± 0.2 (0.9) | 0.9 ± 0.3 (0.9) | 1 ± 0.3 (1) | 1 ± 0.2 (1) |  |  |
 Stage 2 | 0.9 ± 0.2 (0.9) | 1.1 ± 0.2 (1.1) | 1.1 ± 0.2 (1.1) | 1 ± 0.2 (1) |  |  |
Prolactin (ng/mL) | Â | Â | Â | 0.458 | 0.100 | |
 Stage 1 | 19.3 ± 18.8 (12.1) | 20.5 ± 15.1 (13.9) | 17.9 ± 13.6 (12.6) | 14.9 ± 9.6 (10.9) |  |  |
 Stage 2 | 10.8 ± 5.1 (9.3) | 12.5 ± 5.6 (11.2) | 11.6 ± 5.8 (9.3) | 10.1 ± 3.2 (9.4) |  |  |
Insulin (mU/L) | Â | Â | Â | 0.234 | 0.534 | |
 Stage 1 | 7.4 ± 3.1 (6.6) | 6.5 ± 4.9 (5.4) | 6.7 ± 3.8 (6) | 6.6 ± 5.1 (5.3) |  |  |
 Stage 2 | 6.3 ± 1.7 (6.4) | 6.6 ± 2.2 (5.7) | 6.9 ± 3.1 (6.2) | 6.2 ± 3 (5.3) |  |  |
HDL (mg/dL) | Â | Â | Â | 0.058 | 0.922 | |
 Stage 1 | 59 ± 16.6 (54) | 55 ± 12.4 (55) | 58.1 ± 15.9 (55) | 62.1 ± 16.2 (59) |  |  |
 Stage 2 | 60.8 ± 11.7 (57) | 53.1 ± 10.8 (52) | 60.5 ± 11 (55) | 60.8 ± 11.3 (55) |  |  |
Triglycerides (mg/dL) | Â | Â | Â | 0.398 | 0.471 | |
 Stage 1 | 84.5 ± 40.7 (71.5) | 98.5 ± 47.8 (100) | 72.5 ± 36.6 (66.5) | 85.9 ± 38.2 (70) |  |  |
 Stage 2 | 83.5 ± 23.5 (78) | 86.1 ± 27.5 (85) | 75.8 ± 24.8 (73.5) | 78.8 ± 26.6 (71) |  |  |
LDL(mg/dL) | Â | Â | Â | 0.314 | 0.495 | |
 Stage 1 | 97.7 ± 22.5 (100.5) | 93.6 ± 30.4 (88) | 105.3 ± 26.7 (100.5) | 101.1 ± 21.7 (100) |  |  |
 Stage 2 | 103.6 ± 21.5 (103) | 93.1 ± 22.5 (88) | 107.5 ± 24 (101) | 103.1 ± 16.2 (105) |  |  |
Fasting glycemia (mg/dL) | Â | Â | 0.827 | 0.456 | ||
 Stage 1 | 82 ± 6.7 (82.5) | 80.6 ± 6.3 (83) | 79.3 ± 9 (79.5) | 80.8 ± 7.5 (81.5) |  |  |
 Stage 2 | 80.4 ± 4.1 (81) | 78.9 ± 9.6 (82) | 80.1 ± 5.2 (81) | 80.1 ± 4.4 (81) |  |  |
Glycatedhemoglobin (%) | Â | Â | Â | 0.359 | 0.477 | |
 Stage 1 | 5.3 ± 0.4 (5.3) | 5.1 ± 0.3 (5.1) | 5.4 ± 0.4 (5.5) | 5.3 ± 0.3 (5.2) |  |  |
 Stage 2 | 5.2 ± 0.4 (5.2) | 5.2 ± 0.2 (5.3) | 5.2 ± 0.3 (5.2) | 5.3 ± 0.3 (5.2) |  |  |
Hemoglobin (g/dL) | Â | Â | Â | 0.638 | 0.224 | |
 Stage 1 | 13.4 ± 0.8 (13.6) | 13.4 ± 1.3 (13.2) | 13.7 ± 0.8 (13.7) | 13.4 ± 0.8 (13.5) |  |  |
 Stage 2 | 13.8 ± 0.6 (14.1) | 13.7 ± 0.8 (13.5) | 13.2 ± 0.6 (13.2) | 15 ± 7 (13.2) |  |  |