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Fig. 5 | BMC Women's Health

Fig. 5

From: CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Fig. 5

Drug–gene interaction network based on differentially expressed genes and related drugs. The gene–drug interactions retrieved from the DGIdb database shows genes that are targeted therapeutically or prioritized for drug development. White parallelograms represents predicted drugs, red circles represents up-regulated genes, green circles represent down-regulated genes. The outer circle color indicates the gene belongs to the module: module 1, light purple; module 2, dark blue; module 3, bright yellow. Grey connections represent unknown interaction relationships. Red T connections represent inhibitor relationships, yellow T connections represent antagonist relationships, green arrows represent agonist and partial agonist relationships; black connections represent agonist/antagonist relationships; light blue connections represent binder relationships; dark blue connections represent binder/antagonist relationships

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