Predictive factors for failure of the levonorgestrel releasing intrauterine system in women with heavy menstrual bleeding

Table 2 Univariate and multivariate analysis of predictors of failure of the LNG-IUS

Characteristics	Univariable analysis			Multivariable analysis
	RR	95% CI	p-value	RR	95% CI	p-value
Study arm (cohort vs RCT)	1.02	0.76–1.39	.88	1.03	0.76–1.38	.87
Age (≤ 45 vs > 45)	1.57	1.13–2.16	.004	1.51	1.10–2.09	.012
BMI (≥ 25 vs < 25)	0.91	0.67–1.23	.54	0.97	0.72–1.31	.86
Caesarean section	1.36	0.97–1.89	.10
Vaginal delivery	0.89	0.62–1.27	.49
Previous treatment HMB	1.07	0.80–1.45	.64
Anticoagulants	1.32	0.78–2.24	.52
Dysmenorrhea
Present versus non-present	1.04	0.75–1.44	0.83
Severe versus none/mild/moderate	1.44	1.06–1.94	.034	1.36	1.01–1.82	.041
PBAC-score (≥ 425 vs < 425)	1.11	0.82–1.50	.49	1.08	0.81–1.43	.61

BMI, Body Mass Index; HMB, heavy menstrual bleeding; PBAC, Pictorial Blood Assessment Chart. Imputed data: BMI n = 60, caesarean section N = 3, previous treatment HMB N = 1, anticoagulants N = 1, dysmenorrhea N = 12, PBAC = 39. Multivariate analysis preceded by a forced entry method

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