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Table 3 Effect of BMI in subjects with, and without, PCOS: Reproductive hormones

From: Effect of body mass index (BMI) on phenotypic features of polycystic ovary syndrome (PCOS) in Singapore women: a prospective cross-sectional study

Variables Patient category BMI Mean ± SD Model A Model B Model C
Fold change Adjusted difference (95% CI) Fold change Adjusted difference (95% CI) Fold change Adjusted difference (95% CI)
Testosterone (nmol/L) Healthy Normal 1.10 ± 0.05 1.0 Ref     
High 1.12 ± 0.06 1.02 0.12 (− 0.12, 0.36) 1.0 Ref   
PCOS Normal 2.05 ± 0.08 1.86 0.86 (0.58, 1.15)*** 1.83 0.74 (0.42, 1.07)*** 1.0 Ref
High 2.06 ± 0.07 1.87 0.93 (0.66, 1.21)*** 1.84 0.82 (0.52, 1.12)*** 1.0 0.07 (− 0.27, 0.41)
ADT (nmol/L) Healthy Normal 7.77 ± 0.49 1.0 Ref     
High 6.82 ± 0.59 0.88 − 0.01 (− 2.78, 2.76) 1.0 Ref   
PCOS Normal 11.64 ± 0.77 1.50 4.17 (0.91, 7.43)** 1.71 4.18 (0.47, 7.89)* 1.0 Ref
High 10.08 ± 0.71 1.30 2.40 (− 0.76, 5.57) 1.48 2.41 (− 1.03, 5.85) 0.87 − 1.77 (− 5.67, 2.14)
DHEAS (µmol/L) Healthy Normal 5.28 ± 0.18 1.0 Ref     
High 4.93 ± 0.22 0.93 0.12 (− 0.80, 1.04) 1.0 Ref   
PCOS Normal 5.95 ± 0.29 1.13 0.76 (− 0.33, 1.84) 1.21 0.64 (− 0.60, 1.88) 1.0 Ref
High 6.23 ± 0.26 1.18 1.24 (0.19, 2.29)* 1.26 1.12 (− 0.03, 2.27) 1.05 0.48 (− 0.82, 1.78)
DHT (nmol/L) Healthy Normal 1.22 ± 0.08 1.0 Ref     
High 1.38 ± 0.10 1.13 0.28 (− 0.19, 0.75) 1.0 Ref   
PCOS Normal 1.49 ± 0.13 1.22 0.13 (− 0.42, 0.68) 1.22 − 0.15 (− 0.78, 0.48) 1.0 Ref
High 1.84 ± 0.12 1.51 0.73 (0.19, 1.26)** 1.33 0.45 (− 0.14, 1.03) 1.23 0.59 (− 0.07, 1.25)
SHBG (nmol/L) Healthy Normal 67.36 ± 2.18 1.0 Ref     
High 43. 56 ± 2.65 0.65 − 23.36 (− 34.59, − 12.14)** 1.0 Ref   
PCOS Normal 61.34 ± 3.44 0.91 − 9.08 (− 22.29, 4.14) 1.41 14.29 (− 0.80, 29.37) 1.0 Ref
High 32.04 ± 3.14 0.48 − 32.91 (− 45.73, − 20.08)*** 0.74 − 9.54 (− 23.51, 4.43) 0.52 − 23.83 (− 39.68, − 7.98)***
FAI Healthy Normal 2.03 ± 0.29 1.0 Ref     
High 3.48 ± 0.35 1.71 1.70*(0.21, 3.20)* 1.0 Ref   
PCOS Normal 4.19 ± 0.45 2.06 2.04 (0.30, 3.79)* 1.20 0.34 (− 1.66, 2.34) 1.0 Ref
High 9.45 ± 0.41 4.66 6.97 (5.28, 8.67)*** 2.72 5.27 (3.42, 7.12)*** 2.26 4.93 (2.84, 7.02)***
LH (IUL) Healthy Normal 4.74 ± 0.33 1.0 Ref     
High 4.04 ± 0.39 0.85 − 0.77 (− 2.42, 0.87) 1.0 Ref   
PCOS Normal 9.13 ± 0.49 1.93 4.61 (2.69, 6.52)*** 2.26 5.38 (3.22, 7.54)*** 1.0 Ref
High 8.11 ± 0.45 1.71 2.02 (0.18, 3.86)* 2.01 2.79 (0.80, 4.79)** 0.89 − 2.58 (− 4.83, − 0.34)*
FSH (IUL) Healthy Normal 7.94 ± 0.19 1.0 Ref     
High 6.88 ± 0.30 0.87 − 0.62 (− 1.61, 0.37) 1.0 Ref   
PCOS Normal 7.67 ± 0.23 0.97 − 0.69 (− 1.85, 0.47) 1.11 0.07 (− 1.40, 1.26) 1.0 Ref
High 6.29 ± 0.28 0.79 − 1.62 (− 2.75, − 0.49)** 0.91 1.00 (− 2.23, 0.23) 0.82 − 0.93 (− 2.32, 0.46)
Estradiol (pmol/L) Healthy Normal 175.03 ± 5.22 1.0 Ref     
High 172.96 ± 6.28 0.99 2.26 (− 28.02, 32.53) 1.0 Ref   
PCOS Normal 168.85 ± 8.22 0.96 − 1.67 (− 37.73, 34.40) 0.98 − 3.92 (− 44.88, 37.03) 1.0 Ref
High 190.70 ± 7.46 1.09 23.18 (− 11.42, 57.79) 1.10 20.92 (− 16.67, 58.51) 1.13 24.85 (− 18.02, 67.71)
  1. ADT, androstenedione; DHEAS, dehydroepiandrosterone sulphate; DHT, dihydrotestosterone; SHBG, sex hormone binding globulin; FAI, free androgen index; LH, luteinizing hormone; FSH, Follicle stimulating hormone